Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration
| العنوان: | Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration |
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| المؤلفون: | Maja B. Thomassen, Mats Bue, Maiken Stilling, Mathias Alrø Fichtner Bendtsen, Josefine Slater, Jakob Hansen, Kristina Öbrink-Hansen, Kjeld Søballe, Pelle Hanberg |
| المصدر: | Bone & Joint Research, Vol 10, Iss 1, Pp 60-67 (2021) Bone & Joint Research Bendtsen, M A F, Bue, M, Hanberg, P E, Slater, J, Thomassen, M, Hansen, J, Søballe, K, Öbrink-Hansen, K M & Stilling, M 2021, ' Flucloxacillin bone and soft tissue concentrations assessed by microdialysis in pigs after intravenous and oral administration ', Bone and Joint Research, vol. 10, no. 1, pp. 60-67 . https://doi.org/10.1302/2046-3758.101.BJR-2020-0250.R1 |
| بيانات النشر: | British Editorial Society of Bone & Joint Surgery, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Microdialysis, lcsh:Diseases of the musculoskeletal system, 030106 microbiology, bone, Flucloxacillin, 03 medical and health sciences, 0302 clinical medicine, Animal model, Oral administration, Medicine, Orthopedics and Sports Medicine, 030212 general & internal medicine, Bone, flucloxacillin, business.industry, animal model, Osteomyelitis, osteomyelitis, Soft tissue, Perioperative, Antimicrobial, medicine.disease, infection, Anesthesia, Surgery, lcsh:RC925-935, Infection, business, medicine.drug |
| الوصف: | Aims Flucloxacillin is commonly administered intravenously for perioperative antimicrobial prophylaxis, while oral administration is typical for prophylaxis following smaller traumatic wounds. We assessed the time, for which the free flucloxacillin concentration was maintained above the minimum inhibitory concentration ( fT > MIC) for methicillin-susceptible Staphylococcus aureus in soft and bone tissue, after intravenous and oral administration, using microdialysis in a porcine model. Methods A total of 16 pigs were randomly allocated to either intravenous (Group IV) or oral (Group PO) flucloxacillin 1 g every six hours during a 24-hour period. Microdialysis was used for sampling in cancellous and cortical bone, subcutaneous tissue, and the knee joint. In addition, plasma was sampled. The flucloxacillin fT > MIC was evaluated using a low MIC target (0.5 μg/ml) and a high MIC target (2.0 μg/ml). Results Intravenous administration resulted in longer fT > MIC (0.5 μg/ml) compared to oral administration, except for cortical bone. In Group IV, all pigs reached a concentration of 0.5 μg/ml in all compartments. The mean fT > MIC (0.5 μg/ml) was 149 minutes (95% confidence interval (CI) 119 to 179; range 68 to 323) in subcutaneous tissue and 61 minutes (95% CI 29 to 94; range 0 to 121) to 106 minutes (95% CI 76 to 136; range 71 to 154) in bone tissue. In Group PO, 0/8 pigs reached a concentration of 0.5 μg/ml in all compartments. For the high MIC target (2.0 μg/ml), fT > MIC was close to zero minutes in both groups across compartments. Conclusion Although intravenous administration of flucloxacillin 1 g provided higher fT > MIC for the low MIC target compared to oral administration, concentrations were surprisingly low, particularly for bone tissue. Achievement of sufficient bone and soft tissue flucloxacillin concentrations may require a dose increase or continuous administration. Cite this article: Bone Joint Res 2021;10(1):60–67. |
| تدمد: | 2046-3758 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaa60d726d845a5a363f81a1aea4eced https://doi.org/10.1302/2046-3758.101.bjr-2020-0250.r1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....aaa60d726d845a5a363f81a1aea4eced |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20463758 |
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