Sarcopenia as an independent predictor for venous thromboembolism events in bladder cancer patients undergoing radical cystectomy
| العنوان: | Sarcopenia as an independent predictor for venous thromboembolism events in bladder cancer patients undergoing radical cystectomy |
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| المؤلفون: | Changli Wu, Jie Gao, Yingxin Shi, Dawei Tian, Yu Zhang, Dian-Sheng Zhou |
| المصدر: | Supportive Care in Cancer. 30:1191-1198 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Sarcopenia, medicine.medical_specialty, Multivariate analysis, medicine.medical_treatment, Subgroup analysis, Cystectomy, Postoperative Complications, Internal medicine, Diabetes mellitus, Humans, Medicine, Retrospective Studies, Univariate analysis, Bladder cancer, business.industry, Incidence (epidemiology), Venous Thromboembolism, musculoskeletal system, medicine.disease, body regions, Urinary Bladder Neoplasms, Oncology, business, human activities |
| الوصف: | Sarcopenia has been proved to be related to the prognosis of patients with bladder cancer (BC) after radical cystectomy (RC). The relationship between sarcopenia and the occurrence of venous thromboembolism (VTE) after RC is unclear. We collected data of 252 BC patients treated with RC at our institution. Data was obtained from the electronic medical record database. Sarcopenia was defined by the third lumbar vertebra skeletal muscle index (SMI) which was measured using preoperative computed tomography. The primary outcome was the incidence of VTE within 30 days after the surgery in sarcopenia and non-sarcopenia groups. Outcomes between the two cohorts were compared using univariate analysis. Multivariate logistic regression was used to control for differences between cohorts. Two hundred fifty-two patients were enrolled, of which 85 (33.7%) patients were in sarcopenia group, while 167 (66.3%) patients were not in sarcopenia group. The incidence of total VTE in sarcopenia group was higher than that in the extended group (10.6% vs. 1.8%, p = 0.005). Sarcopenia did not cause an increase in other postoperation 30 days complications (all p > 0.05). Multivariate analysis confirmed sarcopenia was independently associated with increased odds of VTE (OR = 4.18, 95% CI [1.01–17.27]; p = 0.048). Subgroup analysis showed that patients with VTE tended to be older (76.5 vs 66.0, p = 0.025) and have higher proportion of diabetes (58.3% vs 14.2%, p |
| تدمد: | 1433-7339 0941-4355 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab0f80fbe72bfdae236dc8e7aae69a9 https://doi.org/10.1007/s00520-021-06423-2 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....aab0f80fbe72bfdae236dc8e7aae69a9 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14337339 09414355 |
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