Three-month Follow-up Study of Survivors of Coronavirus Disease 2019 after Discharge
| العنوان: | Three-month Follow-up Study of Survivors of Coronavirus Disease 2019 after Discharge |
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| المؤلفون: | Wei Fu, Xiaorong Wang, Li-Mei Liang, Nanchuan Jiang, Yaya Zhou, Xin-Liang He, Bohan Yang, Wan-Li Ma |
| المصدر: | Journal of Korean Medical Science |
| بيانات النشر: | The Korean Academy of Medical Sciences, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Vital capacity, medicine.medical_specialty, High-resolution computed tomography, Time Factors, Vital Capacity, Antibodies, Viral, Pulmonary function testing, 03 medical and health sciences, FEV1/FVC ratio, Young Adult, 0302 clinical medicine, Lung Function, Internal medicine, Forced Expiratory Volume, Lymphopenia, Palpitations, Medicine, SARS-CoV-2 Antibody, Humans, Lung volumes, 030212 general & internal medicine, Exertion, Survivors, Lung, Aged, medicine.diagnostic_test, business.industry, SARS-CoV-2, Follow-up, Troponin I, COVID-19, General Medicine, Infectious Diseases, Microbiology & Parasitology, Middle Aged, Patient Discharge, respiratory tract diseases, medicine.anatomical_structure, Original Article, Female, medicine.symptom, business, Tomography, X-Ray Computed, Follow-Up Studies |
| الوصف: | Background Most patients including health care workers (HCWs) survived the coronavirus disease 2019 (COVID-19), however, knowledge about the sequelae of COVID-19 after discharge remains limited. Methods A prospectively observational 3-month follow-up study evaluated symptoms, dynamic changes of severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) IgG and IgM, lung function, and high resolution computed tomography (HRCT) of survivors of COVID-19 after discharge at Wuhan Union Hospital, China. Results Seventy-six survivors (55 females) with a mean age of 41.3 ± 13.8 years were enrolled, and 65 (86%) were HCWs. A total of 69 (91%) patients had returned to their original work at 3-months after discharge. Most of the survivors had symptoms including fever, sputum production, fatigue, diarrhea, dyspnea, cough, chest tightness on exertion and palpitations in the three months after discharge. The serum troponin-I levels during the acute illness showed high correlation with the symptom of fatigue after hospital discharge (r = 0.782; P = 0.008) and lymphopenia was correlated with the symptoms of chest tightness and palpitations on exertion of patients after hospital discharge (r = −0.285, P = 0.027; r = −0.363, P = 0.004, respectively). The mean values of forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), FEV1/FVC, total lung capacity and diffusion capacity were all normal (> 80% predicted) and lung HRCTs returned to normal in most of the patients (82%), however, 42% of survivors had mild pulmonary function abnormalities at 3-months after discharge. SARS-CoV-2 IgG turned negative in 11% (6 of 57 patients), 8% (4 of 52 patients) and 13% (7 of 55 patients), and SARS-CoV-2 IgM turned negative in 72% (41 of 57 patients), 85% (44 of 52 patients) and 87% (48 of 55 patients) at 1-month, 2-months and 3-months after discharge, respectively. Conclusion Infection by SARS-CoV-2 caused some mild impairments of survivors within the first three months of their discharge and the duration of SARS-CoV-2 antibody was limited, which indicates the necessity of long-term follow-up of survivors of COVID-19. Graphical Abstract |
| اللغة: | English |
| تدمد: | 1598-6357 1011-8934 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab2a926e58995eb70829e2ab1747cac http://europepmc.org/articles/PMC7721559 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....aab2a926e58995eb70829e2ab1747cac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15986357 10118934 |
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