Co-encapsulation of gemcitabine and tocotrienols in nanovesicles enhanced efficacy in pancreatic cancer
| العنوان: | Co-encapsulation of gemcitabine and tocotrienols in nanovesicles enhanced efficacy in pancreatic cancer |
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| المؤلفون: | Chun-Wai Mai, Mohd Zulkefeli, Ju-Yen Fu, Geetha Maniam |
| المصدر: | Nanomedicine. 16:373-389 |
| بيانات النشر: | Future Medicine Ltd, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | endocrine system diseases, Biomedical Engineering, Medicine (miscellaneous), Bioengineering, 02 engineering and technology, Polyethylene glycol, Development, Pharmacology, Deoxycytidine, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Cell Line, Tumor, Pancreatic cancer, medicine, Humans, General Materials Science, Niosome, Cytotoxicity, Cholesterol, Tocotrienols, Vesicle, 021001 nanoscience & nanotechnology, medicine.disease, Gemcitabine, In vitro, Pancreatic Neoplasms, chemistry, 030220 oncology & carcinogenesis, Nanoparticles, 0210 nano-technology, medicine.drug |
| الوصف: | Aim: To synthesize niosomes co-encapsulating gemcitabine (GEM) and tocotrienols, and physicochemically characterize and evaluate the antipancreatic effects of the nanoformulation on Panc 10.05, SW 1990, AsPC-1 and BxPC-3 cells. Materials & methods: Niosomes-entrapping GEM and tocotrienols composed of Span 60, cholesterol and D-α-tocopheryl polyethylene glycol 1000 succinate were produced by Handjani-Vila and film hydration methods. Results: The film hydration produced vesicles measuring 161.9 ± 0.5 nm, approximately 50% smaller in size than Handjani-Vila method, with maximum entrapment efficiencies of 20.07 ± 0.22% for GEM and 34.52 ± 0.10% for tocotrienols. In Panc 10.05 cells, GEM’s antiproliferative effect was enhanced 2.78-fold in combination with tocotrienols. Niosomes produced a significant ninefold enhancement in cytotoxicity of the combination, supported by significantly higher cellular uptake of GEM in the cells. Conclusion: This study is a proof of concept on the synthesis of dual-drug niosomes and their efficacy on pancreatic cancer cells in vitro. |
| تدمد: | 1748-6963 1743-5889 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab8e2536a7fa63af96b897ea4a67b26 https://doi.org/10.2217/nnm-2020-0374 |
| رقم الأكسشن: | edsair.doi.dedup.....aab8e2536a7fa63af96b897ea4a67b26 |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 17486963 17435889 |
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