Estimating the burden of influenza-related and associated hospitalizations and deaths in France: An eight-season data study, 2010-2018
| العنوان: | Estimating the burden of influenza-related and associated hospitalizations and deaths in France: An eight-season data study, 2010-2018 |
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| المؤلفون: | Magali Lemaitre, Fouad Fayssoil, Fabrice Carrat, Pascal Crepey, Jacques Gaillat, Gaetan Gavazzi, O. Launay, Anne Mosnier, Marie-Cecile Levant, Mathieu Uhart |
| المساهمون: | IQVIA, Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département Méthodes quantitatives en santé publique (METIS), Recherche en Pharmaco-épidémiologie et Recours aux Soins (REPERES), Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP), Centre Hospitalier Annecy-Genevois [Saint-Julien-en-Genevois], CHU Grenoble, CIC Cochin Pasteur (CIC 1417), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôtel-Dieu-Groupe hospitalier Broca-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Réseau des Groupes Régionaux d'Observation de la Grippe (GROG), Coordination nationale, Sanofi Pasteur [Lyon, France], Sanofi, Gestionnaire, HAL Sorbonne Université 5 |
| المصدر: | Influenza and Other Respiratory Viruses Influenza and Other Respiratory Viruses, 2022, 16 (4), pp.717-725. ⟨10.1111/irv.12962⟩ |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Pulmonary and Respiratory Medicine, Epidemiology, Incidence, Public Health, Environmental and Occupational Health, mortality, Hospitalization, Infectious Diseases, Cost of Illness, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, Influenza, Human, Humans, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, France, human, Seasons |
| الوصف: | International audience; BackgroundIn France, each year, influenza viruses are responsible for seasonal epidemics leading to 2–6 million cases. Influenza can cause severe disease that may lead to hospitalization or death. As severe disease may be due to the virus itself or to disease complications, estimating the burden of severe influenza is complex. The present study aimed at estimating the epidemiological and economic burden of severe influenza in France during eight consecutive influenza seasons (2010–2018).MethodsInfluenza-related hospitalization and mortality data and patient characteristics were taken from the French hospital information database, PMSI. An ecological approach using cyclic regression models integrating the incidence of influenza syndrome from the Sentinelles network supplemented the PMSI data analysis in estimating excess hospitalization and mortality (CépiDc—2010–2015) and medical costs.ResultsEach season, the average number of influenza-related hospitalizations was 18,979 (range: 8627–44,024), with an average length of stay of 8 days. The average number of respiratory hospitalizations indirectly related with influenza (i.e., influenza associated) was 31,490 (95% confidence interval [CI]: 24,542–39,012), with an average cost of €141 million (range: 54–217); 70% of these hospitalizations and 77% of their costs concerned individuals ≥65 years of age (65+). More than 90% of excess mortality was in 65+ subjects.ConclusionsThe combination of two complementary approaches allowed estimation of both influenza-related and associated hospitalizations and deaths and their burden in France, showing the substantial impact of complications. The present study highlighted the major public health burden of influenza and its severe complications, especially in 65+ subjects. |
| وصف الملف: | application/pdf |
| تدمد: | 1750-2659 1750-2640 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aaf88718635982fefd64f0fb5f404884 https://pubmed.ncbi.nlm.nih.gov/35014194 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....aaf88718635982fefd64f0fb5f404884 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17502659 17502640 |
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