TFDP3 Regulates Epithelial-Mesenchymal Transition in Breast Cancer
| العنوان: | TFDP3 Regulates Epithelial-Mesenchymal Transition in Breast Cancer |
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| المؤلفون: | Yanchen Liu, Ming Chu, Kailin Yin, Yue-Dan Wang |
| المصدر: | PLoS ONE, Vol 12, Iss 1, p e0170573 (2017) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, CA15-3, Oncology, Microarrays, Physiology, medicine.medical_treatment, Invasive Ductal Carcinoma, lcsh:Medicine, Pathology and Laboratory Medicine, Biochemistry, Metastasis, Targeted therapy, Testis, Breast Tumors, Basic Cancer Research, Tumor Microenvironment, Medicine and Health Sciences, Small interfering RNAs, lcsh:Science, Multidisciplinary, biology, Nucleic acids, Bioassays and Physiological Analysis, Female, Transcription Factor DP1, Research Article, medicine.medical_specialty, Epithelial-Mesenchymal Transition, Clinical Pathology, Breast Neoplasms, Research and Analysis Methods, Transfection, Carcinomas, 03 medical and health sciences, Breast cancer, Cell Line, Tumor, Internal medicine, Breast Cancer, Tissue Repair, Genetics, medicine, Humans, PTEN, Epithelial–mesenchymal transition, Non-coding RNA, Molecular Biology Techniques, Molecular Biology, Wound Healing, Biology and life sciences, lcsh:R, Cancers and Neoplasms, Cancer, medicine.disease, Gene regulation, 030104 developmental biology, HIF1A, biology.protein, Cancer research, RNA, lcsh:Q, Gene expression, Physiological Processes |
| الوصف: | Breast cancer remains a lethal disease to women due to lymph node metastasis, the tumor microenvironment, secondary resistance and other unknown factors. Several important transcription factors involved in this disease, such as PTEN, p53 and beta-catenin, have been identified and researched in-depth as candidates for targeted therapy in breast cancer. TFDP3 is a new, promising candidate for transcriptional regulation in breast cancer, although it was first identified in hepatocellular carcinoma. Here, we demonstrate that TFDP3 is expressed in a variety of malignancies, normal testis tissue and breast cancer cell lines and thus provide evidence that TFDP3 is a cancer-testis antigen. We illustrate that overexpression or silencing TFDP3 interferes with epithelial-mesenchymal transition but does not influence cell proliferation, indicating that the TFDP3 protein acts as a transcription factor during epithelial-mesenchymal transition. These data highlight that TFDP3 is expressed in breast cancer, that it is a member of the cancer-testis antigen family and that it functions as a regulator in epithelial-mesenchymal transition. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab99678889057e53e2850afc94b7c96e http://europepmc.org/articles/PMC5256886?pdf=render |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ab99678889057e53e2850afc94b7c96e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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