Residual Corticosteroid Production in Autoimmune Addison Disease
| العنوان: | Residual Corticosteroid Production in Autoimmune Addison Disease |
|---|---|
| المؤلفون: | Per Dahlqvist, Kaja Grønning, Jeanette Wahlberg, Guri Grimnes, Bjørn G. Nedrebø, Jakob Skov, Åse Bjorvatn Sævik, Olle Kämpe, Synnove Emblem Holte, Anne Lise Dahle, Marcus Quinkler, Stina Therese Sollid, Marianne Øksnes, Eystein S. Husebye, Trine Finnes, Aneta Tomkowicz, Paal Methlie, Siri Carlsen, Anna-Karin Åkerman, Sophie Bensing, Charlotte Höybye, Katerina Simunkova, Ingrid Nermoen, Susanna Fonneland Valland, Anders Palmstrøm Jørgensen, Aleksandra Debowska |
| المصدر: | Journal of Clinical Endocrinology and Metabolism 2430–2441 The Journal of Clinical Endocrinology and Metabolism |
| بيانات النشر: | Oxford University Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, residual function, Adrenal failure, adrenal steroids, Autoimmune Addison disease, cortisol, primary adrenal insufficiency, Biochemistry, Gastroenterology, chemistry.chemical_compound, Endocrinology, Addison Disease, Adrenal Cortex Hormones, Corticosterone, Cosyntropin, Clinical Research Article, Middle Aged, VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710, Endokrinologi och diabetes, Corticosteroid, Female, AcademicSubjects/MED00250, Glucocorticoid, medicine.drug, Adult, medicine.medical_specialty, medicine.drug_class, Fludrocortisone, Context (language use), Adrenocorticotropic hormone, Endocrinology and Diabetes, Internal medicine, medicine, Humans, Rheumatology and Autoimmunity, Reumatologi och inflammation, business.industry, Biochemistry (medical), VDP::Medisinske Fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710, Cross-Sectional Studies, chemistry, Mineralocorticoid, business |
| الوصف: | Context Contrary to current dogma, growing evidence suggests that some patients with autoimmune Addison disease (AAD) produce corticosteroids even years after diagnosis. Objective To determine frequencies and clinical features of residual corticosteroid production in patients with AAD. Design Two-staged, cross-sectional clinical study in 17 centers (Norway, Sweden, and Germany). Residual glucocorticoid (GC) production was defined as quantifiable serum cortisol and 11-deoxycortisol and residual mineralocorticoid (MC) production as quantifiable serum aldosterone and corticosterone after > 18 hours of medication fasting. Corticosteroids were analyzed by liquid chromatography–tandem mass spectrometry. Clinical variables included frequency of adrenal crises and quality of life. Peak cortisol response was evaluated by a standard 250 µg cosyntropin test. Results Fifty-eight (30.2%) of 192 patients had residual GC production, more common in men (n = 33; P Conclusion In established AAD, one-third of the patients still produce GCs even decades after diagnosis. Residual production is more common in men and in patients with shorter disease duration but is not associated with adrenal crises or quality of life. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abd6a8274469de94f8751253a4c18d8b https://hdl.handle.net/10037/20133 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....abd6a8274469de94f8751253a4c18d8b |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |