Relationship between dietary macronutrient composition and non-alcoholic fatty liver disease in lean and non-lean populations: a cross-sectional study
| العنوان: | Relationship between dietary macronutrient composition and non-alcoholic fatty liver disease in lean and non-lean populations: a cross-sectional study |
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| المؤلفون: | Hossein Ajdarkosh, Bahareh Amirkalali, Esmaeel Gholizadeh, Masoudreza Sohrabi, Hossein Nobakht, Nima Motamed, Mahmoodreza Khoonsari, Mansooreh Maadi, Farhad Zamani |
| المصدر: | Public Health Nutrition. 24:6178-6190 |
| بيانات النشر: | Cambridge University Press (CUP), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_specialty, Cross-sectional study, Population, Medicine (miscellaneous), Disease, Logistic regression, Gastroenterology, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Risk Factors, Internal medicine, medicine, Humans, Macronutrient composition, 030212 general & internal medicine, education, education.field_of_study, Nutrition and Dietetics, business.industry, Fatty liver, Public Health, Environmental and Occupational Health, Non alcoholic, Nutrients, medicine.disease, Cross-Sectional Studies, 030211 gastroenterology & hepatology, Ultrasonography, business |
| الوصف: | Objective:The current study aimed to customize dietary changes for lean patients with non-alcoholic fatty liver disease (NAFLD).Design:The current study was done with a population-based cross-sectional design. The FFQ was used to analyse dietary macronutrient intake and ultrasonography results for NAFLD diagnosis. The study subjects were divided into the lean and non-lean groups based on their BMI (< 25 and ≥ 25). Multivariable logistic regression was used to evaluate the relationship between dietary macronutrients and NAFLD. Substitution analyses were also performed.Setting:Amol and its suburban areas in Iran.Participants:Adults in the age range of 18 to < 65 with full relevant data.Results:Among the total study subjects (2308), 46·7 % had fatty liver. The substitution of polysaccharides for animal protein and SFA in the lean group resulted in a significant NAFLD reduction, whereas the substitution of SFA for all types of macronutrients, except for n-6 and mono-disaccharides, led to a significant increase in NAFLD (P < 0·05). In non-lean participants, the substitution of MUFA for mono-disaccharides resulted in a significant reduction of NAFLD (P < 0·05). In this group, the substitution of SFA and mono-disaccharides for MUFA, and n-6 for all macronutrients, except vegetable protein and SFA, were significantly related to an increase in NAFLD (P < 0·05).Conclusions:Lower lean NAFLD is correlated with increasing polysaccharides in exchange for SFA and animal protein intake, whereas lower non-lean NAFLD is correlated with increasing MUFA in exchange for mono-disaccharides and reducing n-6 and SFA. |
| تدمد: | 1475-2727 1368-9800 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfb96de8eeb6391c179987a82da379a https://doi.org/10.1017/s1368980021001762 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....abfb96de8eeb6391c179987a82da379a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752727 13689800 |
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