Performance of a clinical risk prediction model for inhibitor formation in severe haemophilia A
| العنوان: | Performance of a clinical risk prediction model for inhibitor formation in severe haemophilia A |
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| المؤلفون: | Flora Peyvandi, Mohsen Saleh Elalfy, Roberta Palla, Carla Valsecchi, Vijay Ramanan, Samantha C. Gouw, Frits R. Rosendaal, Shermarke Hassan, Isabella Garagiola, Mehran Karimi, Amal El-Beshlawy, Pier Mannuccio Mannucci, Peyman Eshghi |
| المساهمون: | Paediatric Haematology, Amsterdam Reproduction & Development (AR&D) |
| المصدر: | Haemophilia, 27(4), e441-e449. Wiley-Blackwell Haemophilia |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Risk, medicine.medical_specialty, Calibration (statistics), Haemophilia A, Population, haemophilia A, 030204 cardiovascular system & hematology, Gene mutation, immunogenicity, Haemophilia, Hemophilia A, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, inhibitors, medicine, Humans, Family history, education, Clinical Haemophilia, Genetics (clinical), education.field_of_study, business.industry, Hematology, General Medicine, Original Articles, prediction, medicine.disease, factor VIII, Calibration, Mutation, Severe haemophilia A, Original Article, business, Predictive modelling, 030215 immunology |
| الوصف: | Background There is a need to identify patients with haemophilia who have a very low or high risk of developing inhibitors. These patients could be candidates for personalized treatment strategies. Aims The aim of this study was to externally validate a previously published prediction model for inhibitor development and to develop a new prediction model that incorporates novel predictors. Methods The population consisted of 251 previously untreated or minimally treated patients with severe haemophilia A enrolled in the SIPPET study. The outcome was inhibitor formation. Model discrimination was measured using the C-statistic, and model calibration was assessed with a calibration plot. The new model was internally validated using bootstrap resampling. Results Firstly, the previously published prediction model was validated. It consisted of three variables: family history of inhibitor development, F8 gene mutation and intensity of first treatment with factor VIII (FVIII). The C-statistic was 0.53 (95% CI: 0.46-0.60), and calibration was limited. Furthermore, a new prediction model was developed that consisted of four predictors: F8 gene mutation, intensity of first treatment with FVIII, the presence of factor VIII non-neutralizing antibodies before treatment initiation and lastly FVIII product type (recombinant vs. plasma-derived). The C-statistic was 0.66 (95 CI: 0.57-0.75), and calibration was moderate. Using a model cut-off point of 10%, positive- and negative predictive values were 0.22 and 0.95, respectively. Conclusion Performance of all prediction models was limited. However, the new model with all predictors may be useful for identifying a small number of patients with a low risk of inhibitor formation. |
| اللغة: | English |
| تدمد: | 1351-8216 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abff4be0f2457e12fc0e537a41c34aa9 https://pure.amc.nl/en/publications/performance-of-a-clinical-risk-prediction-model-for-inhibitor-formation-in-severe-haemophilia-a(d9ac9526-c39b-45f2-a0dd-69d6d14907ba).html |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....abff4be0f2457e12fc0e537a41c34aa9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13518216 |
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