Avian Influenza H7N9 Virus Adaptation to Human Hosts
| العنوان: | Avian Influenza H7N9 Virus Adaptation to Human Hosts |
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| المؤلفون: | Hadia Syahirah Abd Raman, Muhammad Farhan Sjaugi, Li Chuin Chong, Asif M. Khan, Swan Tan, J. T. August, Siew Chinn Fong, Nik Elena Nik Mohamed |
| المساهمون: | KHAN, MOHAMMAD ASİF |
| المصدر: | Viruses Volume 13 Issue 5 Viruses, Vol 13, Iss 871, p 871 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, animal structures, Adaptation, Biological, motifs, Human pathogen, adaptation, Biology, Influenza A Virus, H7N9 Subtype, medicine.disease_cause, Microbiology, Article, Virus, influenza virus, diversity, Birds, H7N9, 03 medical and health sciences, 0302 clinical medicine, Orthomyxoviridae Infections, Species Specificity, Virology, Influenza, Human, medicine, Animals, Humans, 030212 general & internal medicine, avian viruses, chemistry.chemical_classification, Transmission (medicine), Host (biology), Zoonosis, Genetic Variation, zoonosis, medicine.disease, QR1-502, Influenza A virus subtype H5N1, Amino acid, 030104 developmental biology, Infectious Diseases, Amino Acid Substitution, chemistry, host, Influenza in Birds, Host-Pathogen Interactions, surveillance, RNA, Viral, Adaptation, human viruses |
| الوصف: | Avian influenza virus A (H7N9), after circulating in avian hosts for decades, was identified as a human pathogen in 2013. Herein, amino acid substitutions possibly essential for human adaptation were identified by comparing the 4706 aligned overlapping nonamer position sequences (1-9, 2-10, etc.) of the reported 2014 and 2017 avian and human H7N9 datasets. The initial set of virus sequences (as of year 2014) exhibited a total of 109 avian-to-human (A2H) signature amino acid substitutions. Each represented the most prevalent substitution at a given avian virus nonamer position that was selectively adapted as the corresponding index (most prevalent sequence) of the human viruses. The majority of these avian substitutions were long-standing in the evolution of H7N9, and only 17 were first detected in 2013 as possibly essential for the initial human adaptation. Strikingly, continued evolution of the avian H7N9 virus has resulted in avian and human protein sequences that are almost identical. This rapid and continued adaptation of the avian H7N9 virus to the human host, with near identity of the avian and human viruses, is associated with increased human infection and a predicted greater risk of human-to-human transmission. Bezmiâlem Vakıf Üniversitesi Avian Influenza H7N9 Virus Adaptation to Human Hosts |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1999-4915 |
| DOI: | 10.3390/v13050871 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac5da6ec48d1ea12fe00782180420b43 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ac5da6ec48d1ea12fe00782180420b43 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19994915 |
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| DOI: | 10.3390/v13050871 |