C-Reactive Protein Predicts Future Cardiovascular Events in Patients With Carotid Stenosis
| العنوان: | C-Reactive Protein Predicts Future Cardiovascular Events in Patients With Carotid Stenosis |
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| المؤلفون: | Erich Minar, Petra Dick, Oswald Wagner, Oliver Schlager, Markus Exner, Schila Sabeti, Renate Koppensteiner, Wolfgang Mlekusch, Jasmin Amighi, Martin Schillinger |
| المصدر: | Stroke. 38:1263-1268 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Carotid Artery Diseases, Male, medicine.medical_specialty, medicine.medical_treatment, Myocardial Infarction, Comorbidity, Asymptomatic, Disease-Free Survival, Predictive Value of Tests, Risk Factors, Interquartile range, Carotid artery disease, Internal medicine, Humans, Medicine, Carotid Stenosis, Prospective Studies, Myocardial infarction, Stroke, Aged, Ultrasonography, Inflammation, Advanced and Specialized Nursing, business.industry, Vascular disease, Percutaneous coronary intervention, Middle Aged, Prognosis, medicine.disease, Stenosis, C-Reactive Protein, Cardiovascular Diseases, Disease Progression, Cardiology, Female, Neurology (clinical), Radiology, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Follow-Up Studies |
| الوصف: | Background and Purpose— Atherosclerosis is a systemic inflammatory disease. We demonstrated previously that high-sensitivity C-reactive protein (hs-CRP) is associated with short-term progression of carotid atherosclerosis. We now investigated whether baseline levels of hs-CRP predict midterm clinical outcome in these patients. Methods— We prospectively studied 1065 of 1268 consecutive patients who were initially asymptomatic with respect to carotid artery disease and were investigated with serial carotid ultrasound examinations at baseline and after a 6- to 9-month interval. Patients were followed-up clinically for the occurrence of cardiovascular events, a composite of myocardial infarction, percutaneous coronary intervention, coronary artery bypass graft, stroke, and death. Results— We recorded progression of carotid stenosis in 93 patients (9%) after 6 to 9 months, and 381 cardiovascular events in 337 patients (27%) during a median of 3 years of clinical follow-up (interquartile range, 2.5 to 3.5 years). The hs-CRP levels were significantly elevated in patients with progressive carotid stenosis ( P P Conclusion— Inflammation was associated with morphological and clinical progression of atherosclerotic disease. Patients with elevated levels of hs-CRP exhibit an increased risk for adverse cardiovascular outcome attributable to clinical adverse events of progressive atherosclerotic disease. |
| تدمد: | 1524-4628 0039-2499 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac7107f54429f582bad6303078291f59 https://doi.org/10.1161/01.str.0000259890.18354.d2 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ac7107f54429f582bad6303078291f59 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244628 00392499 |
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