Comprehensive analyses of safety and efficacy toward individualizing imatinib dosage in patients with chronic myeloid leukemia
| العنوان: | Comprehensive analyses of safety and efficacy toward individualizing imatinib dosage in patients with chronic myeloid leukemia |
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| المؤلفون: | Soo Young Choi, Soo-Hyun Kim, Dong-Wook Kim, Hayeon Noh, Jangik I. Lee, Kyung-Mi Kee, Dae Young Zang, Hyejin Shin, Su Young Jung, Seon-Young Yang |
| المصدر: | International Journal of Hematology. 111:417-426 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Neutropenia, Time Factors, Adolescent, Imatinib treatment, Gastroenterology, Young Adult, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Internal medicine, medicine, Humans, In patient, Precision Medicine, Aged, Aged, 80 and over, Leukopenia, Hematology, business.industry, Body Weight, Age Factors, Myeloid leukemia, Imatinib, Middle Aged, medicine.disease, Thrombocytopenia, Treatment Outcome, Major Molecular Response, Imatinib Mesylate, Female, Safety, medicine.symptom, business, medicine.drug |
| الوصف: | Safety and efficacy outcomes of imatinib treatment were evaluated using extensive clinical data collected from a total of 1003 patients with newly diagnosed chronic myeloid leukemia in chronic phase between 2001 and 2018. By 12 months of imatinib treatment at a fixed dose of 400 mg/day, 45.4% of patients experienced at least one type of dose-limiting toxicities (DLTs). The DLTs that frequently occurred first were thrombocytopenia (40.0%), neutropenia/leukopenia (14.3%) and dermatological reactions (12.1%). Patients with lighter body weight (≤ 64 kg) and older age (> 43 years) experienced a markedly higher occurrence of first DLTs by 12 months than heavier and younger patients (57.9% vs. 30.1%, p |
| تدمد: | 1865-3774 0925-5710 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac72f57bbb72bd76b5a2ee3a6728460b https://doi.org/10.1007/s12185-019-02805-9 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ac72f57bbb72bd76b5a2ee3a6728460b |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 18653774 09255710 |
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