The central vein sign in multiple sclerosis patients with vascular comorbidities
| العنوان: | The central vein sign in multiple sclerosis patients with vascular comorbidities |
|---|---|
| المؤلفون: | François Guisset, Bernard Dachy, Julie Absil, Pietro Maggi, Vincent Van Pesch, Valentina Lolli, Céline Bugli, Gaetano Perrotta, Marco Pasi, Marie Théaudin, Caroline Pot |
| المساهمون: | UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - SSH/LIDAM/SMCS - Support en méthodologie et calcul statistique (plate-forme technologique), UCL - (SLuc) Service de neurologie |
| المصدر: | Multiple sclerosis Multiple Sclerosis Journal, p. [1-9] (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Multiple Sclerosis, Imaging biomarker, 030204 cardiovascular system & hematology, multiple sclerosis, Veins, 03 medical and health sciences, 0302 clinical medicine, fluids and secretions, Neurologie, medicine, Humans, magnetic resonance imaging, Vein, Central vein sign, Aged, medicine.diagnostic_test, business.industry, cerebral small vessel disease, Multiple sclerosis, Brain, Magnetic resonance imaging, medicine.disease, equipment and supplies, Magnetic Resonance Imaging, medicine.anatomical_structure, Neurology, vascular risk factors, Cerebral Small Vessel Diseases, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery, Sign (mathematics) |
| الوصف: | Background: The central vein sign (CVS) is an imaging biomarker able to differentiate multiple sclerosis (MS) from other conditions causing similar appearance lesions on magnetic resonance imaging (MRI), including cerebral small vessel disease (CSVD). However, the impact of vascular risk factors (VRFs) for CSVD on the percentage of CVS positive (CVS+) lesions in MS has never been evaluated. Objective: To investigate the association between different VRFs and the percentage of CVS+ lesions in MS. Methods: In 50 MS patients, 3T brain MRIs (including high-resolution 3-dimensional T2*-weighted images) were analyzed for the presence of the CVS and MRI markers of CSVD. A backward stepwise regression model was used to predict the combined predictive effect of VRF (i.e. age, hypertension, diabetes, obesity, ever-smoking, and hypercholesterolemia) and MRI markers of CSVD on the CVS. Results: The median frequency of CVS+ lesions was 71% (range: 35%–100%). In univariate analysis, age (p < 0.0001), hypertension (p < 0.001), diabetes (p < 0.01), obesity (p < 0.01), smoking (p < 0.05), and the presence of enlarged-perivascular-spaces on MRI (p < 0.005) were all associated with a lower percentage of CVS+ lesions. The stepwise regression model showed that age and arterial hypertension were both associated with the percentage of CVS+ lesions in MS (adjusted R2 = 0.46; p < 0.0001 and p = 0.01, respectively). Conclusion: The proportion of CVS+ lesions significantly decreases in older and hypertensive MS patients. Although this study was conducted in patients with an already established MS diagnosis, the diagnostic yield of the previously proposed 35% CVS proportion-based diagnostic threshold appears to be not affected. Overall these results suggest that the presence of VRF for CSVD should be taken into account during the CVS assessment. SCOPUS: ar.j info:eu-repo/semantics/published |
| وصف الملف: | 1 full-text file(s): application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac80cd278749833edd46c966f9920e98 http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/312335 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ac80cd278749833edd46c966f9920e98 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |