Role of T-type Calcium Channels in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in Neonatal Rats
| العنوان: | Role of T-type Calcium Channels in Generating Hyperexcitatory Behaviors during Emergence from Sevoflurane Anesthesia in Neonatal Rats |
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| المؤلفون: | Yue Guang Si, Byung Gun Lim, Feng Yan Shen, Bo Cao, Wen Wen, Li Qing Ma, Yang In Kim, Young Beom Kim, Yu Zhang, Meng Deng, Ying Wei Wang |
| المصدر: | Neurosci Bull |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, medicine.medical_specialty, Neurology, Mediodorsal Thalamic Nucleus, Physiology, urologic and male genital diseases, Sevoflurane, Rats, Sprague-Dawley, Calcium Channels, T-Type, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Anesthesiology, medicine, Animals, Anesthesia, Theta Rhythm, Prefrontal cortex, business.industry, General Neuroscience, T-type calcium channel, Electroencephalography, Depolarization, General Medicine, Calcium Channel Blockers, female genital diseases and pregnancy complications, Rats, 030104 developmental biology, Endocrinology, Animals, Newborn, Concomitant, Anesthetics, Inhalation, GABAergic, Female, Original Article, business, Locomotion, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | In the current study, we sought to investigate whether T-type Ca(2+) channels (TCCs) in the brain are involved in generating post-anesthetic hyperexcitatory behaviors (PAHBs). We found that younger rat pups (postnatal days 9–11) had a higher incidence of PAHBs and higher PAHB scores than older pups (postnatal days 16–18) during emergence from sevoflurane anesthesia. The power spectrum of the theta oscillations (4 Hz–8 Hz) in the prefrontal cortex was significantly enhanced in younger pups when PAHBs occurred, while there were no significant changes in older pups. Both the power of theta oscillations and the level of PAHBs were significantly reduced by the administration of TCC inhibitors. Moreover, the sensitivity of TCCs in the medial dorsal thalamic nucleus to sevoflurane was found to increase with age by investigating the kinetic properties of TCCs in vitro. TCCs were activated by potentiated GABAergic depolarization with a sub-anesthetic dose of sevoflurane (1%). These data suggest that (1) TCCs in the brain contribute to the generation of PAHBs and the concomitant electroencephalographic changes; (2) the stronger inhibitory effect of sevoflurane contributes to the lack of PAHBs in older rats; and (3) the contribution of TCCs to PAHBs is not mediated by a direct effect of sevoflurane on TCCs. |
| تدمد: | 1995-8218 1673-7067 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9268077e08952f06c471a733804b2f https://doi.org/10.1007/s12264-019-00461-x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ac9268077e08952f06c471a733804b2f |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 19958218 16737067 |
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