Tissue adhesives for bacterial inhibition in extracorporeal membrane oxygenation cannulae
| العنوان: | Tissue adhesives for bacterial inhibition in extracorporeal membrane oxygenation cannulae |
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| المؤلفون: | Yue Qu, John F. Fraser, India Pearse, Amanda Corley |
| المصدر: | Intensive Care Medicine Experimental Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-9 (2021) |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | food.ingredient, medicine.medical_treatment, Critical Care and Intensive Care Medicine, law.invention, Agar plate, 03 medical and health sciences, 0302 clinical medicine, food, Cyanoacrylate, Staphylococcus epidermidis, law, Extracorporeal membrane oxygenation, medicine, Agar, 030212 general & internal medicine, Research Articles, Bacteria, biology, RC86-88.9, business.industry, Medical emergencies. Critical care. Intensive care. First aid, 030208 emergency & critical care medicine, Tissue adhesive, biology.organism_classification, Antimicrobial, Cannula, surgical procedures, operative, Anesthesia, Infection, business, Central venous catheter |
| الوصف: | Background One of the most serious complications of extracorporeal membrane oxygenation (ECMO) therapy is ECMO cannulae infection, which can occur at quadruple the rate of central venous catheter infections, and significantly impact morbidity and paediatric mortality. The objective of this in vitro observational study was to assess antimicrobial properties of two n-butyl-2-octyl cyanoacrylate tissue adhesive (TA) formulations for bacterial inhibition at peripheral ECMO cannulae insertion sites. Methods Antimicrobial properties were assessed using modified agar disk-diffusion (n = 3) and simulated agar cannulation insertion site (n = 20) models. Both assays used Staphylococcus epidermidis which was seeded at the edge of the TA or dressing. Microorganism inhibition was visually inspected and evidenced by the presence or absence of a TA bacterial inhibition zone at 24 and 72 h. Results Both TAs provided effective barriers to bacterial migration under cannula dressings, to cannula insertion sites and down cannula tunnels. Additionally, both TAs demonstrated distinct zones of inhibition produced when left to polymerise onto agar plates seeded with S. epidermidis. Conclusions N-Butyl-2-octyl cyanoacrylate TA appears to inhibit bacterial growth and migration of S. epidermidis. Application of TA to cannulae insertion sites may therefore be a potential bedside strategy for infection prevention in ECMO cannulae, but requires further testing before being used clinically for this purpose. |
| تدمد: | 2197-425X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad02c787e66af4c4cd3329742317d0fd https://doi.org/10.1186/s40635-021-00388-6 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ad02c787e66af4c4cd3329742317d0fd |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 2197425X |
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