This study aims to investigate the potential association of peripheral inflammatory blood cell parameters with the incidence and progression of chronic kidney disease (CKD) in patients with diabetes.The cross-sectional study included 1192 subjects with diabetes derived from one center. The cohort study included 2060 subjects with diabetes derived from another two centers followed up for 4 years. Logistic regression and Cox proportional hazards models were used to evaluate the association of peripheral inflammatory blood cell with CKD.In the cross-sectional study, neutrophil count performed best as an independent risk factor for CKD (odds ratio 2.556 [95% confidence interval 1.111, 5.879]) even after 1:1 case-control matching for age, gender, history of high blood pressure and duration of diabetes. Spline regression revealed a significant linear association of CKD incidence with continuous neutrophil count in excess of 3.6 × 10This study suggested that neutrophil count is an independent risk factor for progression of CKD in patients with diabetes.背景: 本研究旨在探讨糖尿病人中外周血炎性细胞参数与慢性肾脏疾病(CKD)的发生和发展之间的潜在相关性。 方法: 以1192名来自同一研究中心的受试者作为横断面研究。来自另外两个中心的2060名受试者随访4年，进入队列研究。采用Logistic回归和COX比例风险模型评价外周血炎性细胞与CKD的相关性。 结果: 在横断面研究中，即使在年龄、性别、高血压病史和糖尿病病程进行1:1病例对照匹配后，中性粒细胞计数仍然是CKD的最相关的独立危险因素(OR 2.556[95%CI 1.111，5.879])。样条回归显示CKD发病率与中性粒细胞计数持续超过3.6×10
