Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia
| العنوان: | Neuropsychiatric profiles in patients with Alzheimer′s disease and vascular dementia |
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| المؤلفون: | Goutam Gangopadhyay, Atanu Biswas, Arijit Roy, Asit Kumar Senapati, Malay Kumar Ghoshal, Tushar Kanti Bandyopadhyay, Sujit Sarkhel, Deb Sankar Guin |
| المصدر: | Annals of Indian Academy of Neurology, Vol 17, Iss 3, Pp 325-330 (2014) Annals of Indian Academy of Neurology |
| بيانات النشر: | Medknow, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Pediatrics, medicine.medical_specialty, small vessel disease, Clinical Dementia Rating, Irritability, Dysphoria, lcsh:RC346-429, parasitic diseases, medicine, Dementia, Apathy, cardiovascular diseases, Psychiatry, Vascular dementia, lcsh:Neurology. Diseases of the nervous system, neuropsychiatric inventory, business.industry, vascular dementia, behavioral and psychological symptoms of dementia, medicine.disease, Anxiety, Original Article, Neurology (clinical), Alzheimer disease, biological phenomena, cell phenomena, and immunity, medicine.symptom, Alzheimer's disease, business |
| الوصف: | Background/Aims: The aim of the following study is to compare the behavioral and psychological symptoms of dementia (BPSD) in patients of Alzheimer disease (AD) and vascular dementia (VaD). Materials and Methods: We used National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria for diagnosing AD and National Institute of Neurological Disorders and Stroke-Association International pour la Recherche et l’Enseignement en Neurosciences Criteria for diagnosing VaD. VaD cohort was further subcategorized into small vessel and large vessel disease. The severity of cognitive impairment and the BPSD were studied by means of the Clinical Dementia Rating Scale (CDR) and the Neuropsychiatric Inventory respectively. Results: We studied 50 AD and 50 VaD patients of whom 38 were small vessels and 12 were large vessels VaD. The severity of dementia was comparable in both groups. The agitation/aggression, depression/dysphoria, anxiety, apathy/indifference, irritability, aberrant motor behavior, appetite and eating behavior and night-time behaviors occurred significantly more frequently in patients with VaD than AD. We found a weak positive correlation between the CDR score and the number of neuropsychiatric symptoms per patient in both cohorts. Elation/euphoria, agitation/aggression was significantly more frequent in patients with large vessel in comparison to small vessel VaD. Conclusions: BPSD are common in both types of dementia and they are more severe in VaD than AD when the groups have similar levels of cognitive impairment. |
| تدمد: | 0972-2327 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad0b06ca32017801102aedc4879c64ee https://doi.org/10.4103/0972-2327.138520 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ad0b06ca32017801102aedc4879c64ee |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09722327 |
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