Cannabidiol Confers Neuroprotection in Rats in a Model of Transient Global Cerebral Ischemia: Impact of Hippocampal Synaptic Neuroplasticity
العنوان: | Cannabidiol Confers Neuroprotection in Rats in a Model of Transient Global Cerebral Ischemia: Impact of Hippocampal Synaptic Neuroplasticity |
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المؤلفون: | Jéssica Mendes Bonato, Erika Meyer, Francisco Silveira Guimarães, Marco Aurélio Mori, Bianca Andretto de Mattos, Humberto Milani, Alline C. Campos, Rúbia Maria Weffort de Oliveira |
المصدر: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
بيانات النشر: | Springer Science and Business Media LLC, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | Male, Dendritic spine, Neuroscience (miscellaneous), Hippocampus, Hippocampal formation, Neuroprotection, Cellular and Molecular Neuroscience, Organ Culture Techniques, Neurotrophic factors, Neuroplasticity, medicine, Animals, Cannabidiol, Rats, Wistar, Spatial Memory, Neuronal Plasticity, SINAPSE, business.industry, Rats, Disease Models, Animal, Neurology, Ischemic Attack, Transient, Synapses, Synaptic plasticity, business, Neuroscience, medicine.drug |
الوصف: | Evidence for the clinical use of neuroprotective drugs for the treatment of cerebral ischemia (CI) is still greatly limited. Spatial/temporal disorientation and cognitive dysfunction are among the most prominent long-term sequelae of CI. Cannabidiol (CBD) is a non-psychotomimetic constituent of Cannabis sativa that exerts neuroprotective effects against experimental CI. The present study investigated possible neuroprotective mechanisms of action of CBD on spatial memory impairments that are caused by transient global cerebral ischemia (TGCI) in rats. Hippocampal synaptic plasticity is a fundamental mechanism of learning and memory. Thus, we also evaluated the impact of CBD on neuroplastic changes in the hippocampus after TGCI. Wistar rats were trained to learn an eight-arm aversive radial maze (AvRM) task and underwent either sham or TGCI surgery. The animals received vehicle or 10 mg/kg CBD (i.p.) 30 min before surgery, 3 h after surgery, and then once daily for 14 days. On days 7 and 14, we performed a retention memory test. Another group of rats that received the same pharmacological treatment was tested in the object location test (OLT). Brains were removed and processed to assess neuronal degeneration, synaptic protein levels, and dendritic remodeling in the hippocampus. Cannabidiol treatment attenuated ischemia-induced memory deficits. In rats that were subjected to TGCI, CBD attenuated hippocampal CA1 neurodegeneration and increased brain-derived neurotrophic factor levels. Additionally, CBD protected neurons against the deleterious effects of TGCI on dendritic spine number and the length of dendritic arborization. These results suggest that the neuroprotective effects of CBD against TGCI-induced memory impairments involve changes in synaptic plasticity in the hippocampus. |
تدمد: | 1559-1182 0893-7648 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad1d8861957823c2fac433ffd1042d05 https://doi.org/10.1007/s12035-021-02479-7 |
حقوق: | OPEN |
رقم الأكسشن: | edsair.doi.dedup.....ad1d8861957823c2fac433ffd1042d05 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15591182 08937648 |
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