In vitro and in vivo Effects of Vardenafil (a PDE-5 Inhibitor) on Corpus Cavernosal Smooth Muscle Relaxation in Diabetic Rabbits
| العنوان: | In vitro and in vivo Effects of Vardenafil (a PDE-5 Inhibitor) on Corpus Cavernosal Smooth Muscle Relaxation in Diabetic Rabbits |
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| المؤلفون: | Dimitri P. Mikhailidis, Faiz Mumtaz, David H.W. Lau, Cecil S. Thompson |
| المصدر: | Urologia Internationalis. 82:101-107 |
| بيانات النشر: | S. Karger AG, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Nitroprusside, medicine.medical_specialty, Endothelium, Phosphodiesterase Inhibitors, Sildenafil, Muscle Relaxation, Vasodilator Agents, Urology, Piperazines, Diabetes Mellitus, Experimental, Nitric oxide, chemistry.chemical_compound, Erectile Dysfunction, Vardenafil Dihydrochloride, In vivo, Diabetes mellitus, Internal medicine, medicine, Animals, Sulfones, Cyclic Nucleotide Phosphodiesterases, Type 5, Dose-Response Relationship, Drug, Triazines, business.industry, Imidazoles, Muscle, Smooth, Phosphodiesterase 5 Inhibitors, medicine.disease, Electric Stimulation, Disease Models, Animal, Muscle relaxation, Erectile dysfunction, Endocrinology, medicine.anatomical_structure, chemistry, Vardenafil, Rabbits, business, Penis, medicine.drug |
| الوصف: | Introduction: Diabetes mellitus is associated with impaired cavernosal smooth muscle relaxation (CSMR) and the development of erectile dysfunction (ED). Vardenafil, a phosphodiesterase type 5 inhibitor has been used to treat ED. The aim of this study was to assess the in vitro and in vivo effects of vardenafil on diabetic rabbit CSMR. Methods: Organ bath studies were used. Results: Sodium nitroprusside (SNP)- and electrical field stimulation (EFS)-induced CSMR in diabetic rabbits given the vehicle was significantly impaired when compared with controls. The in vitro addition of vardenafil significantly enhanced SNP-induced CSMR in diabetic animals given the vehicle. SNP-induced CSMR in diabetic animals given in vivo vardenafil was significantly increased when compared with the diabetic untreated group. The in vitro addition of vardenafil significantly enhanced SNP and EFS-induced CSMR in cavernosal tissue taken from diabetic animals given vardenafil in vivo. Conclusions: The present findings suggest that the combination of in vitro and in vivo vardenafil enhance diabetic CSMR, reinforcing the use of vardenafil for the treatment of diabetes-induced ED. |
| تدمد: | 1423-0399 0042-1138 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad696db9e5dc90b4540c63e6015e8680 https://doi.org/10.1159/000176035 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....ad696db9e5dc90b4540c63e6015e8680 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230399 00421138 |
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