Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC
| العنوان: | Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC |
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| المؤلفون: | Mariam Sofi, Kate H. Gartlan, Kuo-Ching Sheng, Leonie K. Ashman, Mark D. Wright, Annemiek B. van Spriel, Vasso Apostolopoulos |
| المساهمون: | University of Groningen |
| المصدر: | European Journal of Immunology, 39(1), 50-55. Wiley European Journal of Immunology, 39, 50-5 European Journal of Immunology, 39, 1, pp. 50-5 |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, HLA CLASS-I, SURFACE, Tetraspanins, Ag presentation, T cell, Immunology, chemical and pharmacologic phenomena, CD8-Positive T-Lymphocytes, Tetraspanin 24, Lymphocyte Activation, Major histocompatibility complex, DC, ANTIGENS, Mice, MOLECULES, MHC CLASS-II, Tetraspanin, Antigen, Co-stimulation, Immune Regulation [NCMLS 2], Antigens, CD, Antigens, Neoplasm, MHC class I, medicine, Animals, Immunology and Allergy, Glycoproteins, MICRODOMAINS, Mice, Knockout, Antigen Presentation, MHC class II, PEPTIDE COMPLEXES, biology, Dendritic Cells, ASSOCIATION, MHC restriction, TAPA-1, Cell biology, Mice, Inbred C57BL, medicine.anatomical_structure, biology.protein, MHC, MEMBRANE |
| الوصف: | Contains fulltext : 81375.pdf (Publisher’s version ) (Closed access) A major question in immunology is how DC can display limited amounts of individual peptide-MHC complexes and still induce cross-linking of T-cell receptors to initiate cellular responses. One suggested mechanism is that MHC exists at the cell surface in high avidity multimers, and tetraspanin proteins, known to laterally associate with both MHC classes I and II, promote MHC multimerisation. To validate this theory, we tested the ability of DC deficient in either one of two typical tetraspanin molecules: CD37 or CD151 to present peptide to Ag-specific T cells. Surprisingly, although they exhibited no developmental or maturation defects, DC lacking either CD37 or CD151 expression were hyper-stimulatory to T cells. We demonstrate that CD37 and CD151 control DC-mediated T-cell activation by two different mechanisms: CD151 regulates co-stimulation whereas CD37 regulates peptide/MHC presentation. The implications of these results on the model suggesting that tetraspanins promote MHC multimerisation are discussed. |
| وصف الملف: | application/pdf |
| تدمد: | 0014-2980 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8bbe1efff330536a7f9e6cf5c9a90b https://doi.org/10.1002/eji.200838798 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ad8bbe1efff330536a7f9e6cf5c9a90b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00142980 |
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