Comprehensive amelioration of high-fat diet-induced metabolic dysfunctions through activation of the PGC-1α pathway by probiotics treatment in mice
| العنوان: | Comprehensive amelioration of high-fat diet-induced metabolic dysfunctions through activation of the PGC-1α pathway by probiotics treatment in mice |
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| المؤلفون: | Chang-Kee Hyun, Bobae Kim, In Suk Choi, Jeonghyeon Kwon, Chungho Lee, Byoung-Kook Kim, Hyunchae Joung |
| المصدر: | PLoS ONE PLoS ONE, Vol 15, Iss 2, p e0228932 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, FGF21, Physiology, Peptide Hormones, Adipose tissue, Gut flora, Biochemistry, Mice, 0302 clinical medicine, Sirtuin 1, Immune Physiology, Brown adipose tissue, Medicine and Health Sciences, Bile, Adiposity, Innate Immune System, Multidisciplinary, biology, Liver Diseases, Fatty liver, Reverse cholesterol transport, food and beverages, Thermogenesis, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, Lipids, Body Fluids, medicine.anatomical_structure, Cholesterol, Adipose Tissue, Liver, Medicine, Brown Adipose Tissue, Cytokines, Adiponectin, Anatomy, Signal Transduction, Research Article, medicine.medical_specialty, Science, Immunology, 030209 endocrinology & metabolism, Gastroenterology and Hepatology, Diet, High-Fat, Microbiology, Bile Acids and Salts, 03 medical and health sciences, Metabolic Diseases, Adipokines, Internal medicine, Glucose Intolerance, medicine, Animals, Dyslipidemias, business.industry, Probiotics, Biology and Life Sciences, Molecular Development, biology.organism_classification, medicine.disease, Lipid Metabolism, Hormones, Gastrointestinal Microbiome, Mice, Inbred C57BL, Fatty Liver, 030104 developmental biology, Endocrinology, Biological Tissue, Metabolic Disorders, Immune System, business, Physiological Processes, Lactobacillus plantarum, Developmental Biology |
| الوصف: | Although the beneficial effects of probiotics in the prevention or treatment of metabolic disorders have been extensively researched, the precise mechanisms by which probiotics improve metabolic homeostasis are still not clear. Given that probiotics usually exert a comprehensive effect on multiple metabolic disorders, defining a concurrent mechanism underlying the multiple effects is critical to understand the function of probiotics. In this study, we identified the SIRT1-dependent or independent PGC-1α pathways in multiple organs that mediate the protective effects of a strain of Lactobacillus plantarum against high-fat diet-induced adiposity, glucose intolerance, and dyslipidemia. L. plantarum treatment significantly enhanced the expression of SIRT1, PPARα, and PGC-1α in the liver and adipose tissues under HFD-fed condition. L. plantarum treated mice also exhibited significantly increased expressions of genes involved in bile acid synthesis and reverse cholesterol transport in the liver, browning and thermogenesis of adipose tissue, and fatty acid oxidation in the liver and adipose tissue. Additionally, L. plantarum treatment significantly upregulated the expressions of adiponectin in adipose tissue, irisin in skeletal muscle and subcutaneous adipose tissue (SAT), and FGF21 in SAT. These beneficial changes were associated with a significantly improved HFD-induced alteration of gut microbiota. Our findings suggest that the PGC-1α-mediated pathway could be regarded as a potential target in the development of probiotics-based therapies for the prevention and treatment of metabolic disorders. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae4131ac86fd1ec98e3dafa40f53d894 https://pubmed.ncbi.nlm.nih.gov/32040532 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ae4131ac86fd1ec98e3dafa40f53d894 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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