Maternal Fatty Acid Status During Pregnancy and Child Autistic Traits
| العنوان: | Maternal Fatty Acid Status During Pregnancy and Child Autistic Traits |
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| المؤلفون: | Vincent W. V. Jaddoe, Akhgar Ghassabian, Jolien Steenweg-de Graaff, Sabine J. Roza, Jolien Rijlaarsdam, Henning Tiemeier, Frank C. Verhulst |
| المصدر: | American Journal of Epidemiology. 183:792-799 |
| بيانات النشر: | Oxford University Press (OUP), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Epidemiology, Offspring, Linoleic acid, Physiology, Biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, Fatty Acids, Omega-6, Fatty Acids, Omega-3, medicine, Animals, Humans, Prospective Studies, Autistic Disorder, Child, Netherlands, Intelligence Tests, chemistry.chemical_classification, 030109 nutrition & dietetics, Fishes, Fatty acid, medicine.disease, Confidence interval, Diet, chemistry, Maternal Exposure, Cohort, Female, Generation R, 030217 neurology & neurosurgery, Polyunsaturated fatty acid |
| الوصف: | ω-3 and ω-6 polyunsaturated fatty acids are important for brain function and development. We examined whether maternal polyunsaturated fatty acid status during pregnancy affects risk of autistic traits in childhood. Within the Generation R cohort, we measured maternal plasma polyunsaturated fatty acid concentrations and the ω-3:ω-6 ratio in midpregnancy (Rotterdam, the Netherlands, 2001-2005). Child autistic traits at 6 years were assessed by using the Social Responsiveness Scale short form in 4,624 children. A lower maternal ω-3:ω-6 ratio during pregnancy was associated with more autistic traits in the offspring (β = -0.008, 95% confidence interval: -0.016, -0.001). In particular, a higher total ω-6 and linoleic acid status were associated with more autistic traits (all P's < 0.05). Associations were independent of child intelligence, suggesting that the fatty acid distribution specifically affects the development of autistic traits in addition to general neurodevelopment. Maternal plasma ω-3 status was not associated with child autistic traits and, consistently, neither was prenatal dietary fish intake. Our study shows that a lower prenatal ω-3:ω-6 ratio is associated with more child autistic traits, which is largely accounted for by higher ω-6 instead of lower ω-3 status. These results suggest a biological pathway between maternal fatty acid intake during pregnancy and autistic traits in the offspring. |
| تدمد: | 1476-6256 0002-9262 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae90d4e8001196e255341502b8fb9901 https://doi.org/10.1093/aje/kwv263 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....ae90d4e8001196e255341502b8fb9901 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14766256 00029262 |
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