Interfaces with Tunable Mechanical and Radiosensitizing Properties
| العنوان: | Interfaces with Tunable Mechanical and Radiosensitizing Properties |
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| المؤلفون: | Albena Ivanisevic, Brady L. Pearce, Nora G. Berg, Prajesh Adhikari, Nathaniel Rohrbaugh, Patrick J. Snyder, Saad A. Khan, Michael W. Nolan |
| المصدر: | ACS Applied Materials & Interfaces. 8:21956-21961 |
| بيانات النشر: | American Chemical Society (ACS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Materials science, Cell Survival, Composite number, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, Ionizing radiation, law.invention, Magazine, law, Microscopy, General Materials Science, Viability assay, chemistry.chemical_classification, Matrigel, Reactive oxygen species, Nanocomposite, Fibroblasts, 021001 nanoscience & nanotechnology, Nanostructures, 0104 chemical sciences, chemistry, Biophysics, Reactive Oxygen Species, 0210 nano-technology |
| الوصف: | We report the fabrication of a composite containing nanostructured GaOOH and Matrigel with tunable radiosensitizing and stiffness properties. Composite characterization was done with microscopy and rheology. The utility of the interface was tested in vitro using fibroblasts. Cell viability and reactive oxygen species assays quantified the effects of radiation dosages and GaOOH concentrations. Fibroblasts' viability decreased with increasing concentration of GaOOH and composite stiffness. During ionizing radiation experiments the presence of the scintillating GaOOH triggered a different cellular response. Reactive oxygen species data demonstrated that one can reduce the amount of radiation needed to modulate the behavior of cells on interfaces with different stiffness containing a radiosensitizing material. |
| تدمد: | 1944-8252 1944-8244 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0339f9828843f1262c0e08f5c7ea4a https://doi.org/10.1021/acsami.5b11639 |
| رقم الأكسشن: | edsair.doi.dedup.....af0339f9828843f1262c0e08f5c7ea4a |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 19448252 19448244 |
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