Allograft outcomes of treated children with kidney transplant who developed plasma cell‐rich acute rejection (PCAR): A single center's experience
| العنوان: | Allograft outcomes of treated children with kidney transplant who developed plasma cell‐rich acute rejection (PCAR): A single center's experience |
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| المؤلفون: | Mouin G. Seikaly, Jose R. Torrealba, Allen R. Hendricks, Chantale Lacelle, Rong Huang, Issa Alhamoud, Daniel Burguete |
| المصدر: | Pediatric Transplantation. 23 |
| بيانات النشر: | Wiley, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Graft Rejection, Male, medicine.medical_specialty, Adolescent, Biopsy, Plasma Cells, Urology, Neutropenia, Plasma cell, Single Center, Malignancy, Kidney transplant, Matched cohort, medicine, Humans, Transplantation, Homologous, Child, Retrospective Studies, B-Lymphocytes, Transplantation, business.industry, Graft Survival, Allografts, medicine.disease, Kidney Transplantation, Treatment Outcome, EBV viremia, medicine.anatomical_structure, Pediatrics, Perinatology and Child Health, Renal allograft, Female, Hypotension, business, Immunosuppressive Agents, Follow-Up Studies, Glomerular Filtration Rate |
| الوصف: | INTRODUCTION PCAR is a rare form of ACR that may compromise renal allografts. This review evaluates the outcomes of a protocol used to treat PCAR (Study group), and compares these outcomes with a matched cohort with ACR (Control group). METHODS A retrospective analysis of 138 of pRTRs who underwent renal allograft biopsies between January 2008 and November 2016. RESULTS Seven biopsies revealed in situ hybridization of EBER-negative PCAR (5%). Three Study group pRTRs lost their grafts within 3 months after rejection (43%). None of the Control group pRTRs lost their graft during this period. At the time of rejection, eGFR was different between the Control and Study groups (27.0 ± 19.9 mL/min per m2 vs 40.0 ± 10.6 mL/min/1.73 m2 , respectively; P |
| تدمد: | 1399-3046 1397-3142 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af43c4eca1d24a24fb45b8c9ce21599e https://doi.org/10.1111/petr.13500 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....af43c4eca1d24a24fb45b8c9ce21599e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13993046 13973142 |
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