Focal brain ischemia in rat: acute changes in brain tissueT1 reflect acute increase in brain tissue water content
| العنوان: | Focal brain ischemia in rat: acute changes in brain tissueT1 reflect acute increase in brain tissue water content |
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| المؤلفون: | Emmanuel L. Barbier, Emmanuelle Grillon, Jean François Payen, Jean Francois LeBas, Christoph Segebarth, Lijun Liu, Chantal Rémy |
| المساهمون: | Neuroimagerie Fonctionnelle et Metabolique, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Emergency and Critical Care Medicine, Second Affiliated Hospital of Soochow University, Dojat, Michel |
| المصدر: | NMR in Biomedicine NMR in Biomedicine, Wiley, 2005, 18 (8), pp.499-506. ⟨10.1002/nbm.979⟩ |
| بيانات النشر: | Wiley, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Pathology, medicine.medical_specialty, MESH: Rats, Body water, Ischemia, Infarction, MESH: Rats, Sprague-Dawley, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, Brain Ischemia, [SDV.IB.MN] Life Sciences [q-bio]/Bioengineering/Nuclear medicine, MESH: Magnetic Resonance Imaging, 030218 nuclear medicine & medical imaging, Rats, Sprague-Dawley, Brain ischemia, MESH: Brain, 03 medical and health sciences, MESH: Body Water, 0302 clinical medicine, Body Water, medicine.artery, Edema, Occlusion, Animals, Humans, Medicine, MESH: Animals, Radiology, Nuclear Medicine and imaging, Spectroscopy, MESH: Humans, business.industry, Brain, MESH: Brain Ischemia, MESH: Infarction, Middle Cerebral Artery, Infarction, Middle Cerebral Artery, medicine.disease, Magnetic Resonance Imaging, MESH: Male, Rats, Cortex (botany), Middle cerebral artery, Molecular Medicine, medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | International audience; Several recent studies have reported changes of brain tissue T(1) in ischemic models during the first minutes after occlusion of the middle cerebral artery (MCA). In order to assess whether these tissue T(1) changes are related to an increase in tissue water content, we performed T(1) (7 T) and tissue water content measurements in a rat model (n = 10, Sprague-Dawley) of focal cerebral ischemia (intraluminal occlusion model). The tissue water content was determined using a gravimetric technique. The animals were divided into two groups: an ischemic group, with an effective MCA occlusion (n = 6) and a control group, with animals having undergone sham surgery but no MCA occlusion (n = 4). In the ipsilateral cortex, the tissue water content was 81.1 +/- 0.7% at 2 h 15 min following ischemic insult (contralateral value: 79.3 +/- 0.5%). Concomitantly, the tissue T(1) in the ipsilateral cortex was 2062 +/- 60 ms at ischemia onset + 1 h (contralateral 1811 +/- 28 ms) and 2100 +/- 38 ms at ischemia onset + 2 h (contralateral 1807 +/- 18 ms). The tissue T(1) and tissue water content values measured in the contralateral area do not differ from the values obtained in the control group. A significant T(1) increase is observed at ischemia onset + 1 h (+ 14%) and ischemia onset (+ 2 h) + 16%, together with a significant increase in tissue water content (+ 2.3%). This suggests that there is an increase in tissue water content concomitant with cell swelling during the first hours of ischemia. |
| وصف الملف: | application/pdf |
| تدمد: | 1099-1492 0952-3480 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af670e76e07906868686355035ea0b7f https://doi.org/10.1002/nbm.979 |
| حقوق: | EMBARGO |
| رقم الأكسشن: | edsair.doi.dedup.....af670e76e07906868686355035ea0b7f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10991492 09523480 |
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