Selecting mixtures on the basis of dietary exposure and hazard data: application to pesticide exposure in the European population in relation to steatosis
| العنوان: | Selecting mixtures on the basis of dietary exposure and hazard data: application to pesticide exposure in the European population in relation to steatosis |
|---|---|
| المؤلفون: | Despo Louca Christodoulou, Waldo J. de Boer, Pieter Spanoghe, José L. Domingo, Urska Blaznik, Marc C. Kennedy, Chris Anagnostopoulos, Amélie Crépet, Hilko van der Voet, Bodil Hamborg Jensen, Jacob D. van Klaveren, Irena Rehurkova, Marie Vanacker, Angelo Moretto, Corinne Sprong, David Senaeve, J. Ruprich, Francesca Metruccio, Liesbeth Jacxsens |
| المساهمون: | Direction de l'Evaluation des Risques (DER), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), National Institute for Public Health and the Environment [Bilthoven] (RIVM), Wageningen University and Research [Wageningen] (WUR), Fera Science Ltd, National Institute of Public Health [Prague], Universitat Rovira i Virgili, Technical University of Denmark [Lyngby] (DTU), Department of Biomedical and Clinical Sciences, University of Milan |
| المصدر: | International Journal of Hygiene and Environmental Health International Journal of Hygiene and Environmental Health, Elsevier, 2019, 222, pp.291-306. ⟨10.1016/j.ijheh.2018.12.002⟩ Crépet, A, Vanacker, M, Sprong, C, de Boer, W, Blaznik, U, Kennedy, M, Anagnostopoulos, C, Christodoulou, D L, Ruprich, J, Rehurkova, I, Domingo, J L, Jensen, B H, Metruccio, F, Moretto, A, Jacxsens, L, Spanoghe, P, Senaeve, D, van der Voet, H & van Klaveren, J 2019, ' Selecting mixtures on the basis of dietary exposure and hazard data: application to pesticide exposure in the European population in relation to steatosis ', International Journal of Hygiene and Environmental Health, vol. 222, no. 2, pp. 291-306 . https://doi.org/10.1016/j.ijheh.2018.12.002 International Journal of Hygiene and Environmental Health, 222(2), 291-306 International Journal of Hygiene and Environmental Health 222 (2019) 2 |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Adolescent, [SDV]Life Sciences [q-bio], Food Contamination, 010501 environmental sciences, Biology, Risk Assessment, 01 natural sciences, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Environmental health, Animals, Humans, Drug Interactions, 030212 general & internal medicine, Child, 0105 earth and related environmental sciences, 2. Zero hunger, No-Observed-Adverse-Effect Level, Data collection, Pesticide residue, Dietary exposure, Pesticide Residues, Public Health, Environmental and Occupational Health, Sparse non-negative matrix underestimation, Environmental Exposure, European population, Middle Aged, Pesticide, Data application, Hazard, Diet, 3. Good health, Europe, Fatty Liver, Cumulative assessment group, Relative potency factors, Biometris, Dietary exposure and hazard, 13. Climate action, Mixture prioritisation, Risk assessment |
| الوصف: | Populations are exposed to mixtures of pesticides through their diet on a daily basis. The question of which substances should be assessed together remains a major challenge due to the complexity of the mixtures. In addition, the associated risk is difficult to characterise. The EuroMix project (European Test and Risk Assessment Strategies for Mixtures) has developed a strategy for mixture risk assessment. In particular, it has proposed a methodology that combines exposures and hazard information to identify relevant mixtures of chemicals belonging to any cumulative assessment group (CAG) to which the European population is exposed via food. For the purposes of this study, food consumption and pesticide residue data in food and drinking water were obtained from national surveys in nine European countries. Mixtures of pesticides were identified by a sparse non-negative matrix underestimation (SNMU) applied to the specific liver steatosis effect in children from 11 to 15 years of age, and in adults from 18 to 64 years of age in nine European countries. Exposures and mixtures of 144 pesticides were evaluated through four different scenarios: (1) chronic exposure with a merged concentration dataset in the adult population, (2) chronic exposure with country-specific concentration datasets in the adult population, (3) acute exposure with a merged concentration dataset in the adult population, and (4) chronic exposure with a merged concentration dataset in the paediatric population. The relative potency factors of each substance were calculated to express their potency relative to flusilazole, which was chosen as the reference compound. The selection of mixtures and the evaluation of exposures for each country were carried out using the Monte Carlo Risk Assessment (MCRA) software. Concerning chronic exposure, one mixture explained the largest proportion of the total variance for each country, while in acute exposure, several mixtures were often involved. The results showed that there were 15 main pesticides in the mixtures, with a high contribution of imazalil and dithiocarbamate. Since the concentrations provided by the different countries were merged in the scenario using merged concentration data, differences between countries result from differences in food consumption behaviours. These results support the approach that using merged concentration data to estimate exposures in Europe seems to be realistic, as foods are traded across European borders. The originality of the proposed approach was to start from a CAG and to integrate information from combined exposures to identify a refined list of mixtures with fewer components. As this approach was sensitive to the input data and required significant resources, efforts should continue regarding data collection and harmonisation among the different aspects within the pesticides regulatory framework, and to develop methods to group substances and mixtures to characterise the risk. |
| وصف الملف: | application/pdf; application/octet-stream |
| اللغة: | English |
| تدمد: | 1438-4639 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb467c343528045871344ccda6c5851 https://hal.archives-ouvertes.fr/hal-03485673 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....afb467c343528045871344ccda6c5851 |
| قاعدة البيانات: | OpenAIRE |
Full Text via ClinicalKey | تدمد: | 14384639 |
|---|