Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach
| العنوان: | Gastric Dysmotility Associated with Accumulation of Mitochondrial A3243G Mutation in the Stomach |
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| المؤلفون: | Tohru Ibi, Masaru Kuriyama, Takeshi Azuma, Akihiro Fujii, Koji Hayashi, Masahiro Ohtani, Makoto Yoneda, Ko Sahashi, Atsushi Muramatsu, H. Nakagawa, Takanori Kumano, Satoru Takabatake |
| المصدر: | Internal Medicine. 43:1126-1130 |
| بيانات النشر: | Japanese Society of Internal Medicine, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Nausea, Stomach Diseases, Gastric motility, DNA, Mitochondrial, Gastroenterology, Internal medicine, Internal Medicine, Gastric mucosa, Humans, Point Mutation, Medicine, Oral mucosa, Child, Antrum, Myoelectric Complex, Migrating, Gastric emptying, business.industry, Stomach, digestive, oral, and skin physiology, General Medicine, Middle Aged, medicine.anatomical_structure, Gastric Emptying, Vomiting, Female, medicine.symptom, Gastrointestinal Motility, business |
| الوصف: | Objective We analyzed the accumulation of a mitochondrial A-to-G mutation at nucleotide position 3243 (A3243G) in the stomach and gastric motility in patients with gastric symptoms, post-prandial nausea/vomiting and epigastralgia. Methods Detection and quantification of A3243G mutation in mtDNA in the gastric mucosa, oral mucosa, leukocyte, and skeletal muscle were performed. Gastric motility was evaluated by gastric myoelectrical activity on electrogastrography (EGG), and gastric emptying was evaluated by measurement of plasma paracetamol concentration before and after meals. Patients or Materials Four patients with A3243G mutation in the leukocyte mtDNA and gastric symptoms were examined. Results The A3243G mutation was detected at higher percentages in the gastric body (69-94% for mutation; mean, 83%) than in the angle portion (37-82%; mean, 52%), the antrum (40-84%; mean, 57%) or leukocytes (28-52%; mean, 39%), and at slightly higher percentages than in the skeletal muscles (45-87%; mean, 70%) or oral mucosae (52-86%; mean, 69%) in the four patients examined. Abnormal EGGs were observed in the three patients examined. The pre-prandial myoelectrical activities were low in these patients (49% in patient 1, 54% in patient 2, 63% in patient 3; normal >70%). The plasma concentrations of paracetamol were low (3.6 μg/ml in patient 1, 2.4 μg/ml in patient 2 |
| تدمد: | 1349-7235 0918-2918 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdb9f4ddff5ffb21e5daa3fd2efd53d https://doi.org/10.2169/internalmedicine.43.1126 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....afdb9f4ddff5ffb21e5daa3fd2efd53d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13497235 09182918 |
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