Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology
| العنوان: | Akkermansia muciniphila and improved metabolic health during a dietary intervention in obesity: relationship with gut microbiome richness and ecology |
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| المؤلفون: | Dao, MC, Everard, A, Aron-Wisnewsky, J, Sokolovska, N, Prifti, E, Verger, EO, Kayser, BD, Levenez, F, Chilloux, J, Hoyles, L, MICRO-Obes Consortium, Dumas, M-E, Rizkalla, SW, Dore, J, Cani, PD, Clément, K |
| المساهمون: | ProdInra, Migration, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut de Cardiométabolisme et Nutrition = Institute of Cardiometabolism and Nutrition [CHU Pitié Salpêtrière] (IHU ICAN), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Université Catholique de Louvain = Catholic University of Louvain (UCL), MetaGenoPolis, Institut National de la Recherche Agronomique (INRA), MICrobiologie de l'ALImentation au Service de la Santé (MICALIS), Institut National de la Recherche Agronomique (INRA)-AgroParisTech, Imperial College London, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Commission of the European Communities |
| المصدر: | Gut Gut, 2016, 65 (3), pp.426-436. ⟨10.1136/gutjnl-2014-308778⟩ Gut, BMJ Publishing Group, 2016, 65 (3), pp.426-436. ⟨10.1136/gutjnl-2014-308778⟩ |
| بيانات النشر: | HAL CCSD, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Blood Glucose, Male, obesity, HOST, [SDV]Life Sciences [q-bio], GASTRIC BYPASS, Gut flora, Overweight, GLUCOSE, Feces, Weight loss, POPULATION, 2. Zero hunger, education.field_of_study, INSULIN-RESISTANCE, biology, Ecology, Gastroenterology, Middle Aged, [SDV] Life Sciences [q-bio], Treatment Outcome, Female, medicine.symptom, SENSITIVITY, Life Sciences & Biomedicine, Akkermansia muciniphila, EXPRESSION, Adult, Diet, Reducing, glucose metabolism, Population, 03 medical and health sciences, Insulin resistance, Verrucomicrobia, MICRO-Obes Consortium, medicine, Humans, education, Triglycerides, BARIATRIC SURGERY, Aged, ADIPOCYTE SIZE, Science & Technology, Gastroenterology & Hepatology, Akkermansia, 1103 Clinical Sciences, biology.organism_classification, medicine.disease, Obesity, Gastrointestinal Microbiome, METAGENOME, 030104 developmental biology, 1114 Paediatrics and Reproductive Medicine, intestinal bacteria, Insulin Resistance, Biomarkers |
| الوصف: | International audience; Objectives :Individuals with obesity and type 2 diabetes differ from lean and healthy individuals in their abundance of certain gut microbial species and microbial gene richness. Abundance of Akkermansia muciniphila, a mucin-degrading bacterium, has been inversely associated with body fat mass and glucose intolerance in mice, but more evidence is needed in humans. The impact of diet and weight loss on this bacterial species is unknown. Our objective was to evaluate the association between faecal A. muciniphila abundance, faecal microbiome gene richness, diet, host characteristics, and their changes after calorie restriction (CR). Design : The intervention consisted of a 6-week CR period followed by a 6-week weight stabilisation diet in overweight and obese adults (N=49, including 41 women). Faecal A. muciniphila abundance, faecal microbial gene richness, diet and bioclinical parameters were measured at baseline and after CR and weight stabilisation. Results : At baseline A. muciniphila was inversely related to fasting glucose, waist-to-hip ratio and subcutaneous adipocyte diameter. Subjects with higher gene richness and A. muciniphila abundance exhibited the healthiest metabolic status, particularly in fasting plasma glucose, plasma triglycerides and body fat distribution. Individuals with higher baseline A. muciniphila displayed greater improvement in insulin sensitivity markers and other clinical parameters after CR. These participants also experienced a reduction in A. muciniphila abundance, but it remained significantly higher than in individuals with lower baseline abundance. A. muciniphila was associated with microbial species known to be related to health. Conclusions : A. muciniphila is associated with a healthier metabolic status and better clinical outcomes after CR in overweight/obese adults. The interaction between gut microbiota ecology and A. muciniphila warrants further investigation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0017-5749 1468-3288 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b00c373cbe29612ec798773336043965 https://hal.inrae.fr/hal-02639895 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b00c373cbe29612ec798773336043965 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00175749 14683288 |
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