Cerebral edema (CE) is the key factor for the development of secondary brain injuries after severe traumatic brain injury (TBI). This edema may be assessed using the averaged Apparent diffusion coefficient (ADC) measured by diffusion-weighted MRI in specified ROI. However, this approach does not take into account the complexity and the heterogeneity of the post traumatic edema. The parametric response map (PRM), a voxel-based analysis technique, is a promising tool to better investigate spatially dispersed changes of ADC over time (1).
