CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy
| العنوان: | CD2 is involved in maintenance and reversal of human alloantigen-specific clonal anergy |
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| المؤلفون: | Gordon J. Freeman, John G. Gribben, Gary S. Gray, James D. Griffin, Lee M. Nadler, Vassiliki A. Boussiotis |
| المصدر: | The Journal of Experimental Medicine |
| بيانات النشر: | Rockefeller University Press, 1994. |
| سنة النشر: | 1994 |
| مصطلحات موضوعية: | Isoantigens, Immunoconjugates, T cell, Lymphocyte, Immunology, CD2 Antigens, HLA-DR7 Antigen, chemical and pharmacologic phenomena, Human leukocyte antigen, Biology, Epitope, Abatacept, Epitopes, Antigen, Antigens, CD, medicine, Humans, Immunology and Allergy, CTLA-4 Antigen, Clonal Anergy, Membrane Glycoproteins, Clonal anergy, Interleukin, hemic and immune systems, Articles, CD58 Antigens, Antigens, Differentiation, Clone Cells, Histocompatibility, medicine.anatomical_structure, B7-1 Antigen, Interleukin-2 |
| الوصف: | Induction and maintenance of a state of T cell unresponsiveness to specific alloantigen would have significant implications for human organ transplantation. Using human histocompatibility leukocyte antigen DR7-specific helper T cell clones, we demonstrate that blockade of the B7 family of costimulatory molecules is sufficient to induce alloantigen-specific T cell clonal anergy. Anergized cells do not respond to alloantigen and a variety of costimulatory molecules, including B7-1, B7-2, intercellular adhesion molecule-1 (ICAM-1), and lymphocyte function-associated molecule (LFA)-3. However, after culture in exogenous interleukin (IL)-2 for at least 7 d, anergized cells can respond to alloantigen in the presence of LFA-3. LFA-3 costimulation subsequently restores responsiveness to alloantigen in the presence of previously insufficient costimulatory signals. Expression of CD2R epitope is downregulated on anergic cells and is restored after 7 d of IL-2 culture. The loss of the CD2R is temporally associated with the inability of anergized cells to respond to LFA-3. These results suggest that in addition to blockade of B7 family members, inhibition of CD2 and, potentially, other costimulatory pathways that might reverse anergy will be necessary to maintain prolonged alloantigen-specific tolerance. |
| تدمد: | 1540-9538 0022-1007 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b06e80b7347c9af1682d0a1af3efeee8 https://doi.org/10.1084/jem.180.5.1665 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b06e80b7347c9af1682d0a1af3efeee8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15409538 00221007 |
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