Black Phosphorus Nanosheets Immobilizing Ce6 for Imaging-Guided Photothermal/Photodynamic Cancer Therapy
| العنوان: | Black Phosphorus Nanosheets Immobilizing Ce6 for Imaging-Guided Photothermal/Photodynamic Cancer Therapy |
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| المؤلفون: | Dongya Wang, Xiaoji Xie, Xiaochen Dong, Qi Zhang, Xiaoyan Yang, Jianhua Zou, Jinjun Shao, Qisen Zhao, Wei Huang, Yunhao Shi |
| المصدر: | ACS Applied Materials & Interfaces. 10:12431-12440 |
| بيانات النشر: | American Chemical Society (ACS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Photosensitizing Agents, Materials science, Biocompatibility, medicine.medical_treatment, Photothermal effect, Cancer therapy, Phosphorus, Photodynamic therapy, Nanotechnology, 02 engineering and technology, Photothermal therapy, 010402 general chemistry, 021001 nanoscience & nanotechnology, 01 natural sciences, Black phosphorus, Nanostructures, 0104 chemical sciences, Nanomaterials, Photochemotherapy, Cell Line, Tumor, medicine, Humans, General Materials Science, Photosensitizer, 0210 nano-technology |
| الوصف: | In preclinical and clinical research, to destroy cancers, particularly those located in deep tissues, is still a great challenge. Photodynamic therapy and photothermal therapy are promising alternative approaches for tissue cancer curing. Black phosphorus (BP)-based nanomaterials, with broad UV–vis near-infrared absorbance and excellent photothermal effect, have shown great potential in biomedical applications. Herein, a biocompatible therapeutic platform, chlorin e6 (Ce6)-decorated BP nanosheets (NSs), has been developed for fluorescence and thermal imaging-guided photothermal and photodynamic synergistic cancer treatment. Taking advantage of the relatively high surface area of exfoliated BP NSs, the PEG-NH2-modified BP NSs (BP@PEG) are loaded with a Ce6 photosensitizer. The resulted BP@PEG/Ce6 NSs not only have good biocompatibility, physiological stability, and tumor-targeting property but also exhibit enhanced photothermal conversion efficiency (43.6%) compared with BP@PEG NSs (28.7%). In addition, BP... |
| تدمد: | 1944-8252 1944-8244 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b071588e17f8f8d3755f34650450789f https://doi.org/10.1021/acsami.8b00276 |
| رقم الأكسشن: | edsair.doi.dedup.....b071588e17f8f8d3755f34650450789f |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 19448252 19448244 |
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