Short-Term Caloric Restriction Attenuates Obesity-Induced Pro-inflammatory Response in Male Rhesus Macaques
| العنوان: | Short-Term Caloric Restriction Attenuates Obesity-Induced Pro-inflammatory Response in Male Rhesus Macaques |
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| المؤلفون: | Allen Jankeel, Mithila Handu, Hollis Wright, Oleg Varlamov, Ilhem Messaoudi |
| المصدر: | Nutrients Volume 12 Issue 2 Nutrients, Vol 12, Iss 2, p 511 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, obesity, medicine.medical_specialty, Adipose Tissue, White, Lipolysis, nonhuman primates, Down-Regulation, Adipose tissue, lcsh:TX341-641, 030209 endocrinology & metabolism, White adipose tissue, Biology, Diet, High-Fat, Monocytes, Article, Muscle hypertrophy, 03 medical and health sciences, 0302 clinical medicine, Immune system, Internal medicine, medicine, Animals, western-style diet, Receptor, Nutrition and Dietetics, Lipogenesis, Hypertrophy, Adrenergic beta-Agonists, Macaca mulatta, adipose tissue, high-fat diet, 030104 developmental biology, Endocrinology, Receptors, Adrenergic, beta-3, Cytokines, caloric restriction, Inflammation Mediators, Adipocyte hypertrophy, lcsh:Nutrition. Foods and food supply, transcriptome, Food Science |
| الوصف: | White adipose tissue (WAT) hypertrophy is an essential hallmark of obesity and is associated with the activation of resident immune cells. While the benefits of caloric restriction (CR) on health span are generally accepted, its effects on WAT physiology are not well understood. We previously demonstrated that short-term CR reverses obesity in male rhesus macaques exposed to a high-fat Western-style diet (WSD). Here, we analyzed subcutaneous WAT biopsies collected from this cohort of animals before and after WSD and following CR. This analysis showed that WSD induced adipocyte hypertrophy and inhibited &beta adrenergic-simulated lipolysis. CR reversed adipocyte hypertrophy, but WAT remained insensitive to &beta adrenergic agonist stimulation. Whole-genome transcriptional analysis revealed that &beta 3-adrenergic receptor and de novo lipogenesis genes were downregulated by WSD and remained downregulated after CR. In contrast, WSD-induced pro-inflammatory gene expression was effectively reversed by CR. Furthermore, peripheral blood monocytes isolated during the CR period exhibited a significant reduction in the production of pro-inflammatory cytokines compared to those obtained after WSD. Collectively, this study demonstrates that short-term CR eliminates an obesity-induced pro-inflammatory response in WAT and peripheral monocytes. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0bb71fc3088e067f74a83d8ce33ab82 https://doi.org/10.3390/nu12020511 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b0bb71fc3088e067f74a83d8ce33ab82 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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