Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study
| العنوان: | Low prevalence of hypopituitarism after traumatic brain injury: a multicenter study |
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| المؤلفون: | Anton A.M. Franken, R Groote Veldman, Johannes A. Romijn, Peter H. Bisschop, Jitske Tiemensma, Ferdinand Roelfsema, Nieke E. Kokshoorn, M. J. E. Wassenaar, Alberto M. Pereira, Nienke Biermasz, Jan W. A. Smit, W A Nieuwlaat |
| المساهمون: | Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam Movement Sciences, Endocrinology, General Internal Medicine |
| المصدر: | European journal of endocrinology / European Federation of Endocrine Societies, 165(2), 225-231. BioScientifica Ltd. European Journal of Endocrinology, 165(2), 225-231 |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Traumatic brain injury, Cross-sectional study, Endocrinology, Diabetes and Metabolism, Hypopituitarism, Cohort Studies, Diagnostic Techniques, Endocrine, Young Adult, Endocrinology, Internal medicine, Prevalence, Adrenal insufficiency, Humans, Medicine, Prospective cohort study, Aged, Netherlands, business.industry, Glasgow Coma Scale, General Medicine, Middle Aged, medicine.disease, Cross-Sectional Studies, Brain Injuries, Female, business, Body mass index, Algorithms, Cohort study |
| الوصف: | ObjectiveHypopituitarism after traumatic brain injury (TBI) is considered to be a prevalent condition. However, prevalence rates differ considerably among reported studies, due to differences in definitions, endocrine assessments of hypopituitarism, and confounding factors, such as timing of evaluation and the severity of the trauma.AimTo evaluate the prevalence of hypopituitarism in a large cohort of TBI patients after long-term follow-up using a standardized endocrine evaluation.Study designCross-sectional study.Patients and methodsWe included 112 patients with TBI, hospitalized for at least 3 days and duration of follow-up >1 year after TBI from five (neurosurgical) referral centers. Evaluation of pituitary function included fasting morning hormone measurements and insulin tolerance test (n=90) or, when contraindicated, ACTH stimulation and/or CRH stimulation tests and a GH releasing hormone–arginine test (n=22). Clinical evaluation included quality of life questionnaires.ResultsWe studied 112 patients (75 males), with median age 48 years and mean body mass index (BMI) 26.7±4.8 kg/m2. Mean duration of hospitalization was 11 (3–105), and 33% of the patients had a severe trauma (Glasgow Coma Scale Hypopituitarism was diagnosed in 5.4% (6/112) of patients: severe GH deficiency (n=3), hypogonadism (n=1), adrenal insufficiency (n=2). Patients diagnosed with pituitary insufficiency had significantly higher BMI (P=0.002).ConclusionIn this study, the prevalence of hypopituitarism during long-term follow-up after TBI was low. Prospective studies are urgently needed to find reliable predictive tools for the identification of patients with a significant pre-test likelihood for hypopituitarism after TBI. |
| اللغة: | English |
| تدمد: | 0804-4643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f3c677209d6c681d3858005f30a541 https://doi.org/10.1530/eje-11-0365 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b0f3c677209d6c681d3858005f30a541 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 08044643 |
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