أعرض في EDS

Elevated proBNP levels are associated with disease severity, cardiac dysfunction, and mortality in congenital diaphragmatic hernia

التفاصيل البيبلوغرافية
العنوان: Elevated proBNP levels are associated with disease severity, cardiac dysfunction, and mortality in congenital diaphragmatic hernia
المؤلفون: Kevin P. Lally, Vikas S. Gupta, Florian Kipfmueller, Pamela A. Lally, Matthew T. Harting, Neil D. Patel
المصدر: Journal of Pediatric Surgery. 56:1214-1219
بيانات النشر: Elsevier BV, 2021.
سنة النشر: 2021
مصطلحات موضوعية: medicine.medical_specialty, Heart Diseases, medicine.drug_class, Cardiomyopathy, Severity of Illness Index, Ventricular Dysfunction, Left, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Internal medicine, Natriuretic Peptide, Brain, Severity of illness, Natriuretic peptide, Humans, Medicine, cardiovascular diseases, Stage (cooking), business.industry, Congenital diaphragmatic hernia, General Medicine, medicine.disease, Pulmonary hypertension, Peptide Fragments, Echocardiography, 030220 oncology & carcinogenesis, Heart failure, Pediatrics, Perinatology and Child Health, Cardiology, Biomarker (medicine), Surgery, Hernias, Diaphragmatic, Congenital, business, hormones, hormone substitutes, and hormone antagonists
الوصف: Cardiac dysfunction is a key determinant of outcome in congenital diaphragmatic hernia (CDH). Pro-b-type natriuretic peptide (proBNP) is used as a prognosticator in heart failure and cardiomyopathy. We hypothesized that proBNP levels would be associated with ventricular dysfunction and high-risk disease in CDH.Patients in the CDH Study Group (CDHSG) from 2015-2019 with at least one proBNP value were included. Ventricular function was determined using echocardiograms from the first 48 h of life.A total of 2,337 patients were identified, and 212 (9%) had at least one proBNP value. Of those, 3 (1.5%) patients had CDHSG stage A defects, 58 (29.6%) B, 111 (56.6%) C, and 24 (12.2%) D. Patients with high-risk defects (Stage C/D) had higher proBNP compared with low-risk defects (Stage A/B) (14,281 vs. 5,025, p = 0.007). ProBNP was significantly elevated in patients who died (median 14,100, IQR 4,377-22,900 vs 4,911, IQR 1,883-9,810) (p0.001). Ventricular dysfunction was associated with higher proBNP than normal ventricular function (8,379 vs. 4,778, p = 0.005). No proBNP value was both sensitive and specific for ventricular dysfunction (AUC=0.61).Among CDH patients, elevated proBNP was associated with high-risk defects, ventricular dysfunction, and mortality. ProBNP shows promise as a biomarker in CDH-associated cardiac dysfunction.
تدمد: 0022-3468
2015-2019
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f70941c775b71a72381159bb51c05e
https://doi.org/10.1016/j.jpedsurg.2021.02.042
حقوق: CLOSED
رقم الأكسشن: edsair.doi.dedup.....b0f70941c775b71a72381159bb51c05e
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00223468
20152019