Isoindolinone Synthesis: Selective Dioxane-Mediated Aerobic Oxidation of Isoindolines
العنوان: | Isoindolinone Synthesis: Selective Dioxane-Mediated Aerobic Oxidation of Isoindolines |
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المؤلفون: | Sinjinee Sardar, Esai Corral, Frank W. Foss, P. Thapa, Brad S. Pierce |
المصدر: | The Journal of Organic Chemistry. 84:1025-1034 |
بيانات النشر: | American Chemical Society (ACS), 2018. |
سنة النشر: | 2018 |
مصطلحات موضوعية: | inorganic chemicals, 010405 organic chemistry, Organic Chemistry, Late stage, Indoprofen, Isoindoline, 010402 general chemistry, 01 natural sciences, Combinatorial chemistry, 0104 chemical sciences, chemistry.chemical_compound, chemistry, medicine, Chemoselectivity, medicine.drug |
الوصف: | N-Alkyl and N-aryl-isoindolinones were prepared by a dioxane-mediated oxidation of isoindoline precursors. The transformation exhibits unique chemoselectivity for isoindonlines. A chiral tertiary (3°)-benzylic position was not racemized during oxidation, and methyl indoprofen was prepared by late stage oxidation. Mechanistic studies suggest a selective H atom transfer, which avoids many known oxidation (by-)products of isoindolinones. |
تدمد: | 1520-6904 0022-3263 |
URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b104aea1bb503efae3baa6ba59ae20e2 https://doi.org/10.1021/acs.joc.8b01920 |
رقم الأكسشن: | edsair.doi.dedup.....b104aea1bb503efae3baa6ba59ae20e2 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 15206904 00223263 |
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