Hepatic Subcapsular Flow as a Significant Diagnostic Marker for Biliary Atresia: A Meta-Analysis
| العنوان: | Hepatic Subcapsular Flow as a Significant Diagnostic Marker for Biliary Atresia: A Meta-Analysis |
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| المؤلفون: | Wan-liang Guo, Jian Wang, Shun-gen Huang, Bin Wu, Jiang Pan, Dongliang Zhao, Ruze Tang, Wenxian Zhi, Lulu Chen, Chao Sun |
| المصدر: | Disease Markers Disease Markers, Vol 2020 (2020) |
| بيانات النشر: | Hindawi Limited, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Medicine (General), medicine.medical_specialty, Clinical Biochemistry, Subgroup analysis, Review Article, Likelihood ratios in diagnostic testing, Gastroenterology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, R5-920, Neonatal Screening, 0302 clinical medicine, Text mining, Biliary Atresia, Predictive Value of Tests, Biliary atresia, Internal medicine, Genetics, medicine, Humans, Molecular Biology, Ultrasonography, business.industry, Biochemistry (medical), Infant, Newborn, Area under the curve, General Medicine, medicine.disease, Sample size determination, Meta-analysis, Diagnostic odds ratio, 030211 gastroenterology & hepatology, Bile Ducts, business |
| الوصف: | Aim. Increasing evidence indicates that hepatic subcapsular flow (HSF) can serve as a noninvasive ultrasonographic marker for the early diagnosis of biliary atresia (BA). However, results regarding its diagnostic accuracy are inconsistent and inconclusive. We conducted this meta-analysis with an aim to systematically evaluate the diagnostic value of HSF in predicting BA. Methods. A comprehensive literature search of four databases was conducted to identify the eligible studies. All analyses were performed using STATA 12.0. Results. Nine studies from eight articles containing 368 patients and 469 controls were included in our meta-analysis. Briefly, the values for pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) were 0.95 (95% CI 0.88-0.98), 0.92 (95% CI 0.85-0.96), 11.6 (95% CI 6.3-21.5), 0.06 (95% CI 0.02-0.14), 201 (95% CI 59-689), and 0.98 (95% CI 0.96-0.99), respectively. Additionally, metaregression along with subgroup analysis based on various covariates revealed the potential sources of heterogeneity and the detailed diagnostic value in each subgroup. Conclusion. Our meta-analysis showed that HSF assay could provide high accuracy in predicting BA patients and non-BA individuals. However, further studies with better design and larger sample size are required to support the results of the present study. |
| تدمد: | 1875-8630 0278-0240 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1331b722364da6d72e4ef73f4676cc1 https://doi.org/10.1155/2020/5262565 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b1331b722364da6d72e4ef73f4676cc1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18758630 02780240 |
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