Proximity-enhanced synthesis of DNA–peptide–DNA triblock molecules
| العنوان: | Proximity-enhanced synthesis of DNA–peptide–DNA triblock molecules |
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| المؤلفون: | Tara MacCulloch, Alexandra Novacek, Nicholas Stephanopoulos |
| المصدر: | Chem Commun (Camb) |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Oligonucleotides, Materials Chemistry, Metals and Alloys, Ceramics and Composites, Nucleic Acid Hybridization, DNA, General Chemistry, Peptides, Article, Catalysis, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials |
| الوصف: | We report a proximity-enhanced method to synthesize a peptide flanked by two different oligonucleotide handles. Our method relies on sequential bioorthogonal reactions, and partial hybridization of the second handle to the first. We demonstrate the synthesis of a protease-responsive DNA "latch" and a cyclic bioactive peptide using this method. |
| تدمد: | 1364-548X 1359-7345 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b144b29fa54e6dff5c0ca66d7945120c https://doi.org/10.1039/d1cc04970d |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b144b29fa54e6dff5c0ca66d7945120c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1364548X 13597345 |
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