Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology
| العنوان: | Comprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology |
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| المؤلفون: | Qi-qiang He, Zhuoyue Bi, Wei Zhu, Yongyi Bi, Cong Liu, Jian Zhang, Cheng-Cao Sun, Lin-Lin Li, Wei Hu, Han Zhang, Qun Zhou, Feng Zhang, Hui-Min Yang, Gong-Jun Tan, Yang-Yi-Yan Song, De-Jia Li |
| المصدر: | Molecular Cancer, Vol 19, Iss 1, Pp 1-23 (2020) Molecular Cancer |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Cancer Research, Micro RNA, RNA, Untranslated, Review, Biology, Exosome, lcsh:RC254-282, Extracellular Vesicles, 03 medical and health sciences, 0302 clinical medicine, Microvesicle, Neoplasms, microRNA, Biomarkers, Tumor, Animals, Humans, RNA, Messenger, Neoplasm Metastasis, Premetastatic niche, Circular RNA, Cancer, Cancer immunology, Tumor microenvironment, Extracellular vesicle, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Long non-coding RNA, Microvesicles, Cell biology, MicroRNAs, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Disease Progression, Molecular Medicine |
| الوصف: | Extracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally divided into exosomes and microvesicles on basis of their origination from the endosomal membrane or the plasma membrane, respectively. EV-mediated bidirectional communication among various cell types supports cancer cell growth and metastasis. EVs derived from different cell types and status have been shown to have distinct RNA profiles, comprising messenger RNAs and non-coding RNAs (ncRNAs). Recently, ncRNAs have attracted great interests in the field of EV-RNA research, and growing numbers of ncRNAs ranging from microRNAs to long ncRNAs have been investigated to reveal their specific functions and underlying mechanisms in the tumor microenvironment and premetastatic niches. Emerging evidence has indicated that EV-RNAs are essential functional cargoes in modulating hallmarks of cancers and in reciprocal crosstalk within tumor cells and between tumor and stromal cells over short and long distance, thereby regulating the initiation, development and progression of cancers. In this review, we discuss current findings regarding EV biogenesis, release and interaction with target cells as well as EV-RNA sorting, and highlight biological roles and molecular mechanisms of EV-ncRNAs in cancer biology. |
| اللغة: | English |
| تدمد: | 1476-4598 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b183893952dfe84fd08615cd62046ff5 http://link.springer.com/article/10.1186/s12943-020-01199-1 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b183893952dfe84fd08615cd62046ff5 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14764598 |
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