Disruption of Homeostasis Based on the Right and Left Hemisphere in Patients with Complex Regional Pain Syndrome
| العنوان: | Disruption of Homeostasis Based on the Right and Left Hemisphere in Patients with Complex Regional Pain Syndrome |
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| المؤلفون: | Do Hyung Kang, Dasom Lee, Jee Youn Moon, Soo Hee Choi, Jae Yeon Lee, Won Joon Lee, Yong Chul Kim, Hyeonjin Kim, Ye Ha Jung |
| المصدر: | Neuroimmunomodulation. 26:276-284 |
| بيانات النشر: | S. Karger AG, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Proton Magnetic Resonance Spectroscopy, Immunology, Thalamus, Functional Laterality, Energy homeostasis, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, medicine, Homeostasis, Humans, Pathological, Neuroinflammation, Endocrine and Autonomic Systems, business.industry, Chronic pain, Middle Aged, medicine.disease, 030227 psychiatry, Peripheral, Complex regional pain syndrome, Neurology, Female, business, Neuroscience, Complex Regional Pain Syndromes, 030217 neurology & neurosurgery |
| الوصف: | Objective: Although the clinical features and pathophysiology of complex regional pain syndrome (CRPS) have been studied in the peripheral and central nervous systems, few plausible pathological interactions are known among the metabolites in these systems. Thus, the purpose of this study was to investigate abnormal relationships and interactions between peripheral metabolites and central neurometabolites in patients with CRPS. Methods: Various metabolites and molecules were measured in the peripheral blood, and central neurometabolites in the right and left thalamus using proton magnetic resonance spectroscopy in 12 patients with CRPS and 11 healthy controls. Interactions between peripheral metabolites in blood and central neurometabolites in the right and left thalamus were also investigated. Results: The interactions between peripheral and central metabolites were different in the right and left hemispheres of healthy subjects, suggesting the presence of right hemisphere-dependent energy homeostasis and left hemisphere-dependent acid-base homeostasis that enables effective functioning. The interactions between central and peripheral metabolites in CRPS patients were distinct from those in healthy individuals, supporting the possibility of abnormal interactions and disrupted homeostasis between peripheral and central metabolites, which may result from neuroinflammation and immune system dysfunction. Conclusion: To the authors’ knowledge, this is the first report describing abnormal metabolic dysfunction and disrupted homeostasis in interactions between metabolites of the peripheral and central nervous systems in CRPS. The approach used to uncover hidden pathophysiologies will improve understanding of how chronic pain can disrupt homeostasis in interactions between two systems and how alternative metabolites can be activated to recover and compensate for pathological dysfunctions in patients with CRPS. |
| تدمد: | 1423-0216 1021-7401 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1cefb195e6cd3ca3cf5c5ce120fa8ec https://doi.org/10.1159/000504140 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....b1cefb195e6cd3ca3cf5c5ce120fa8ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230216 10217401 |
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