A modeling approach for compounds affecting body composition
| العنوان: | A modeling approach for compounds affecting body composition |
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| المؤلفون: | Dorota Kakol-Palm, Rasmus Jansson-Löfmark, Peter Gennemark, Maria Fritsch-Fredin, Madeleine Antonsson, Daniel Hovdal, Gina Hyberg, Karolina Ploj, Pernilla Håkansson, Maria Wigstrand, Johan Gabrielsson, Peter Brodin |
| المصدر: | Journal of Pharmacokinetics and Pharmacodynamics. 40:651-667 |
| بيانات النشر: | Springer Science and Business Media LLC, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Male, Diet, High-Fat, Models, Biological, Fat mass, Mice, Dual action, Appetite Depressants, Drug Discovery, Statistics, Animals, Humans, Obesity, Simulation, Mathematics, Pharmacology, Mathematical model, Body Weight, Data interpretation, Composition (combinatorics), Mice, Inbred C57BL, Energy expenditure, System parameters, Body Composition, Female, Energy Intake, Energy Metabolism, Free parameter |
| الوصف: | Body composition and body mass are pivotal clinical endpoints in studies of welfare diseases. We present a combined effort of established and new mathematical models based on rigorous monitoring of energy intake (EI) and body mass in mice. Specifically, we parameterize a mechanistic turnover model based on the law of energy conservation coupled to a drug mechanism model. Key model variables are fat-free mass (FFM) and fat mass (FM), governed by EI and energy expenditure (EE). An empirical Forbes curve relating FFM to FM was derived experimentally for female C57BL/6 mice. The Forbes curve differs from a previously reported curve for male C57BL/6 mice, and we thoroughly analyse how the choice of Forbes curve impacts model predictions. The drug mechanism function acts on EI or EE, or both. Drug mechanism parameters (two to three parameters) and system parameters (up to six free parameters) could be estimated with good precision (coefficients of variation typically |
| تدمد: | 1573-8744 1567-567X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b208c5ebb8906155f81d0bacebaa42d7 https://doi.org/10.1007/s10928-013-9337-x |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....b208c5ebb8906155f81d0bacebaa42d7 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15738744 1567567X |
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