A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy
| العنوان: | A Glimpse of Various Pathogenetic Mechanisms of Diabetic Nephropathy |
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| المؤلفون: | Yashpal S. Kanwar, Fu You Liu, Ping Xie, Sheldon Chen, Lin Sun |
| المصدر: | Annual Review of Pathology: Mechanisms of Disease. 6:395-423 |
| بيانات النشر: | Annual Reviews, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Kidney, medicine.medical_specialty, Biology, medicine.disease, Article, Pathology and Forensic Medicine, Diabetic nephropathy, medicine.anatomical_structure, Endocrinology, Glycation, Internal medicine, Diabetes mellitus, Cancer research, medicine, Tubulointerstitial fibrosis, Humans, Diabetic Nephropathies, Signal transduction, Protein kinase C, Transforming growth factor |
| الوصف: | Diabetic nephropathy is a well-known complication of diabetes and is a leading cause of chronic renal failure in the Western world. It is characterized by the accumulation of extracellular matrix in the glomerular and tubulointerstitial compartments and by the thickening and hyalinization of intrarenal vasculature. The various cellular events and signaling pathways activated during diabetic nephropathy may be similar in different cell types. Such cellular events include excessive channeling of glucose intermediaries into various metabolic pathways with generation of advanced glycation products, activation of protein kinase C, increased expression of transforming growth factor β and GTP-binding proteins, and generation of reactive oxygen species. In addition to these metabolic and biochemical derangements, changes in the intraglomerular hemodynamics, modulated in part by local activation of the renin-angiotensin system, compound the hyperglycemia-induced injury. Events involving various intersecting pathways occur in most cell types of the kidney. |
| تدمد: | 1553-4014 1553-4006 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b21250fc73dad86f3c23137c33bbee6d https://doi.org/10.1146/annurev.pathol.4.110807.092150 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b21250fc73dad86f3c23137c33bbee6d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15534014 15534006 |
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