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Differential pre-pandemic breast milk IgA reactivity against SARS-CoV-2 and circulating human coronaviruses in Ugandan and American mothers

التفاصيل البيبلوغرافية
العنوان: Differential pre-pandemic breast milk IgA reactivity against SARS-CoV-2 and circulating human coronaviruses in Ugandan and American mothers
المؤلفون: Claire De Carlo, Alisa Fox, Rebecca L.R. Powell, Gonzaga Apungia, Tonny Jimmy Owalla, Thomas G. Egwang, Emmanuel Okurut
المصدر: International Journal of Infectious Diseases, Vol 112, Iss, Pp 165-172 (2021)
International Journal of Infectious Diseases
بيانات النشر: Elsevier, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Microbiology (medical), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), viruses, Breastfeeding, Mothers, Infectious and parasitic diseases, RC109-216, Cross Reactions, Breast milk, Antibodies, Viral, medicine.disease_cause, Cross-reactivity, Breast milk IgA, Article, Pandemic, Humans, Medicine, Uganda, Pandemics, Spike proteins, Milk, Human, biology, business.industry, SARS-CoV-2, Human coronaviruses, virus diseases, COVID-19, Common cold, General Medicine, biology.organism_classification, medicine.disease, United States, Immunoglobulin A, Infectious Diseases, Immunology, biology.protein, Female, Antibody, business, Betacoronavirus
الوصف: OBJECTIVE: Uganda has registered fewer coronavirus disease 2019 (COVID-19) cases and deaths per capita than Western countries. The lower numbers of cases and deaths might be due to pre-existing cross-immunity induced by circulating common cold human coronaviruses (HCoVs) before the COVID-19 pandemic. To investigate pre-existing mucosal antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, a comparison was performed of IgA reactivity to SARS-CoV-2 and HCoVs in milk from mothers collected in 2018. METHODS: Ugandan and United States milk samples were run on an ELISA to measure specific IgA to SARS-CoV-2 and HCoVs NL63, OC43, HKU1, and 229E spike proteins. Pooled plasma from United States SARS-CoV-2-positive and negative cases were positive and negative controls, respectively. RESULTS: One Ugandan mother had high milk IgA reactivity against all HCoVs and SARS-CoV-2 spike proteins. Ugandan mothers had significantly higher IgA reactivity against the betacoronavirus HCoV-OC43 than United States mothers (P = 0.018). By contrast, United States mothers had significantly higher IgA reactivity against the alphacoronaviruses HCoV-229E and HCoV-NL63 than Ugandan mothers (P < 0.0001 and P = 0.035, respectively). CONCLUSION: Some Ugandan mothers have pre-existing HCoV-induced IgA antibodies against SARS-CoV-2, which may be passed to infants via breastfeeding.
اللغة: English
تدمد: 1201-9712
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b254959f1dab384c196fae6a12a18b42
http://www.sciencedirect.com/science/article/pii/S1201971221007475
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....b254959f1dab384c196fae6a12a18b42
قاعدة البيانات: OpenAIRE
الوصف
تدمد:12019712