Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration
| العنوان: | Expression of the Human Herpesvirus 6A Latency-Associated Transcript U94A Disrupts Human Oligodendrocyte Progenitor Migration |
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| المؤلفون: | Brittany Lopez, Jessica M Hogestyn, David J. Mock, Christopher J. Folts, Christoph Pröschel, Andrew Campbell, Margot Mayer-Pröschel |
| المصدر: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) |
| بيانات النشر: | Springer Science and Business Media LLC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Science, Herpesvirus 6, Human, Oligodendrocyte progenitor, Human metabolism, Biology, Article, Viral Proteins, 03 medical and health sciences, Myelin, 0302 clinical medicine, Cell Movement, Virus latency, medicine, Humans, Latency (engineering), Cells, Cultured, Oligodendrocyte Precursor Cells, Multidisciplinary, Human Herpesvirus 6A, Mechanism (biology), medicine.disease, Virus Latency, Cell biology, 030104 developmental biology, medicine.anatomical_structure, nervous system, Immunology, Medicine, 030217 neurology & neurosurgery, Human herpesvirus, Demyelinating Diseases |
| الوصف: | Progression of demyelinating diseases is caused by an imbalance of two opposing processes: persistent destruction of myelin and myelin repair by differentiating oligodendrocyte progenitor cells (OPCs). Repair that cannot keep pace with destruction results in progressive loss of myelin. Viral infections have long been suspected to be involved in these processes but their specific role remains elusive. Here we describe a novel mechanism by which HHV-6A, a member of the human herpesvirus family, may contribute to inadequate myelin repair after injury. |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b265604aa151542ec4da3066d11066f3 https://doi.org/10.1038/s41598-017-04432-y |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b265604aa151542ec4da3066d11066f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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