Hepatitis B-core Antibody Positive Donors in Liver Transplantation and Their Impact on Graft Survival: Evidence From The Liver Match Cohort Study
| العنوان: | Hepatitis B-core Antibody Positive Donors in Liver Transplantation and Their Impact on Graft Survival: Evidence From The Liver Match Cohort Study |
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| المؤلفون: | Angelico M, Nardi A, Marianelli T, Caccamo L, Romagnoli R, Tisone G, Pinna AD, Avolio AW, Fagiuoli S, Burra P, Strazzabosco M, Nanni Costa A, U Cillo, P Caraceni, P L Toniutto, M Salizzoni, G Bertolotti, D Patrono, L De Carlis, A Slim, J M E Mangoni, G Rossi, B Antonelli, V Mazzaferro, E Regalia, C Sposito, M Colledan, V Corno, F Tagliabue, S Marin, A Vitale, E Gringeri, M Donataccio, D Donataccio, U Baccarani, D Lorenzin, D Bitetto, U Valente, M Gelli, P Cupo, G E Gerunda, G Rompianesi, G L Grazi, A Cucchetti, C Zanfi, A Risaliti, M G Faraci, A Anselmo, I Lenci, D Sforza, S Agnes, M Di Mugno, G M Ettorre, L Miglioresi, G Vennarecci, Roma Sapienza, P Berloco, M Rossi, S Ginanni-Corradini, A Molinaro, F Calise, V Scuderi, O Cuomo, C Migliaccio, L Lupo, G Notarnicola, B Gridelli, R Volpes, S Li Petri, F Zamboni, G Carbotta, S Dedola, C Gavrila, A Ricci, F Vespasiano |
| المساهمون: | Angelico, M, Nardi, A, Marianelli, T, Caccamo, L, Romagnoli, R, Tisone, G, Pinna, A, Avolio, A, Fagiuoli, S, Burra, P, Strazzabosco, M, Costa, A, M, Angelico, A, Nardi, T, Marianelli, L, Caccamo, R, Romagnoli, G, Tisone, Ad, Pinna, Aw, Avolio, S, Fagiuoli, P, Burra, M, Strazzabosco, A, Nanni Costa, Cillo, U, Caraceni, P, L Toniutto, P, Salizzoni, M, Bertolotti, G, Patrono, D, De Carlis, L, Slim, A, E Mangoni, J M, Rossi, G, Antonelli, B, Mazzaferro, V, Regalia, E, Sposito, C, Colledan, M, Corno, V, Tagliabue, F, Marin, S, Vitale, A, Gringeri, E, Donataccio, M, Donataccio, D, Baccarani, U, Lorenzin, D, Bitetto, D, Valente, U, Gelli, M, Cupo, P, E Gerunda, G, Rompianesi, G, L Grazi, G, Cucchetti, A, Zanfi, C, Risaliti, A, G Faraci, M, Anselmo, A, Lenci, I, Sforza, D, Agnes, S, Di Mugno, M, M Ettorre, G, Miglioresi, L, Vennarecci, G, Sapienza, Roma, Berloco, P, Rossi, M, Ginanni-Corradini, S, Molinaro, A, Calise, F, Scuderi, V, Cuomo, O, Migliaccio, C, Lupo, L, Notarnicola, G, Gridelli, B, Volpes, R, Li Petri, S, Zamboni, F, Carbotta, G, Dedola, S, Gavrila, C, Ricci, A, Vespasiano, F, Mario Angelico, Alessandra Nardi, Tania Marianelli, Lucio Caccamo, Renato Romagnoli, Giuseppe Tisone, Antonio D. Pinna, Alfonso W. Avolio, Stefano Fagiuoli, Patrizia Burra, Mario Strazzabosco, Alessandro Nanni Costa, For the Liver Match Investigators [.., Paolo Caraceni, ] |
| بيانات النشر: | Elsevier, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, HBsAg, medicine.medical_treatment, Settore MED/18 - CHIRURGIA GENERALE, graft survival, De novo HBV infection, Donor Risk Index, Donor-recipient matching, HBcAb positive donors, Liver transplantation, medicine.disease_cause, Gastroenterology, Cohort Studies, Model for End-Stage Liver Disease, MED/12 - GASTROENTEROLOGIA, HBcAb positive donor, liver transplantation, Prospective Studies, Prospective cohort study, Settore MED/12 - Gastroenterologia, Hepatitis B Core Antigen, Hazard ratio, Middle Aged, Hepatitis B, Hepatitis B Core Antigens, Tissue Donors, Italy, Hepatocellular carcinoma, HCV, outcome, Female, Human, hbcab positive donors, Adult, medicine.medical_specialty, donor risk index, HBcAb positive, Tissue Donor, survival, donor-recipient matching, Donor Selection, Hepatitis B Antibodie, HBV, liver transplantation, Internal medicine, medicine, Humans, de novo hbv infection, Hepatitis B Antibodies, Donor-recipient matching, HBcAb positive donors, De novo HBV infection, Donor Risk Index, Aged, Hepatitis B virus, Hepatitis, Hepatology, business.industry, LIVER TRANSPLANTATION, medicine.disease, Surgery, Prospective Studie, Liver Transplantation, Graft Survival, Cohort Studie, business |
| الوصف: | Background & Aims: The appropriate allocation of grafts from HBcAb positive donors in liver transplantation is crucial, yet a consensus is still lacking. Methods: We evaluated this issue within Liver Match, a prospective observational Italian study. Data from 1437 consecutive, first transplants performed in 2007-2009 using grafts from deceased heart beating donors were analyzed (median follow-up: 1040 days). Of these, 219 (15.2%) were HBcAb positive. Sixty-six HBcAb positive grafts were allocated to HBsAg positive and 153 to HBsAg negative recipients. Results: 329 graft losses occurred (22.9%): 66 (30.1%) among 219 recipients of HBcAb positive grafts, and 263 (21.6%) among 1218 recipients of HBcAb negative grafts. Graft survival was lower in recipients of HBcAb positive compared to HBcAb negative donors, with unadjusted 3-year graft survival of 0.69 (s.e. 0.032) and 0.77 (0.013), respectively (log-rank, p = 0.0047). After stratifying for recipient HBsAg status, this difference was only observed among HBsAg negative recipients (log rank, p = 0.0007), 3-year graft survival being excellent (0.88, s.e. 0.020) among HBsAg positive recipients, regardless of the HBcAb donor status (log rank, p = 0.4478). Graft loss due to de novo HBV hepatitis occurred only in one patient. At Cox regression, hazard ratios for graft loss were: MELD (1.30 per 10 units, p = 0.0002), donor HBcAb positivity (1.56, p = 0.0015), recipient HBsAg positivity (0.43, p |
| وصف الملف: | STAMPA |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b26fbccf8ddb3279575521860538e735 http://hdl.handle.net/10807/37930 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b26fbccf8ddb3279575521860538e735 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |