Building the Framework for Standardized Clinical Laboratory Reporting of Next-generation Sequencing Data for Resistance-associated Mutations in Mycobacterium tuberculosis Complex
| العنوان: | Building the Framework for Standardized Clinical Laboratory Reporting of Next-generation Sequencing Data for Resistance-associated Mutations in Mycobacterium tuberculosis Complex |
|---|---|
| المؤلفون: | Lakshmi Jayashankar, Jeffrey A. Tornheim, Timothy C. Rodwell, Angela M. Starks, Paolo Miotto, Matteo Zignol, Timothy M Walker, Jennifer L. Gardy, Daniela Maria Cirillo, Marco Schito |
| المصدر: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, vol 69, iss 9 Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Tuberculosis, Genotype, Standardization, 030106 microbiology, Antitubercular Agents, MEDLINE, Microbial Sensitivity Tests, Computational biology, Medical and Health Sciences, Microbiology, DNA sequencing, Terminology, Mycobacterium tuberculosis, 03 medical and health sciences, Drug Resistance, Multiple, Bacterial, Tuberculosis, Multidrug-Resistant, Humans, Medicine, interpretation, standardization, reporting, biology, business.industry, High-Throughput Nucleotide Sequencing, Sequence Analysis, DNA, Biological Sciences, biology.organism_classification, medicine.disease, 3. Good health, Viewpoints, 030104 developmental biology, Infectious Diseases, tuberculosis, Mycobacterium tuberculosis complex, Infectious disease (medical specialty), Mutation, next-generation sequencing, business |
| الوصف: | Tuberculosis is the primary infectious disease killer worldwide, with a growing threat from multidrug-resistant cases. Unfortunately, classic growth-based phenotypic drug susceptibility testing (DST) remains difficult, costly, and time consuming, while current rapid molecular testing options are limited by the diversity of antimicrobial-resistant genotypes that can be detected at once. Next-generation sequencing (NGS) offers the opportunity for rapid, comprehensive DST without the time or cost burden of phenotypic tests and can provide useful information for global surveillance. As access to NGS expands, it will be important to ensure that results are communicated clearly, consistent, comparable between laboratories, and associated with clear guidance on clinical interpretation of results. In this viewpoint article, we summarize 2 expert workshops regarding a standardized report format, focusing on relevant variables, terminology, and required minimal elements for clinical and laboratory reports with a proposed standardized template for clinical reporting NGS results for Mycobacterium tuberculosis. An expert consensus process was used to develop a standardized framework for reporting and communicating clinically relevant next-generation sequencing data from Mycobacterium tuberculosis for guiding drug treatment options. |
| وصف الملف: | application/pdf |
| تدمد: | 1537-6591 1058-4838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29e8c57431bd019392fd7b5fea813dd https://doi.org/10.1093/cid/ciz219 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b29e8c57431bd019392fd7b5fea813dd |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 10584838 |
|---|