Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients
| العنوان: | Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients |
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| المؤلفون: | Terry Ting-Yu Chiou, Jin-Bor Chen, Hwee-Yeong Ng, Po-Jung Wu, Shu-Ching Lien, Pei-Ying Tsai, Wen-Chin Lee, Chien-Hsing Wu, Chien-Te Lee |
| المصدر: | BioMed Research International BioMed Research International, Vol 2018 (2018) |
| بيانات النشر: | Hindawi, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Cirrhosis, DNA Copy Number Variations, Article Subject, medicine.medical_treatment, 030232 urology & nephrology, lcsh:Medicine, medicine.disease_cause, DNA, Mitochondrial, Thiobarbituric Acid Reactive Substances, Gastroenterology, Antioxidants, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Non-alcoholic Fatty Liver Disease, Renal Dialysis, Risk Factors, Internal medicine, Nonalcoholic fatty liver disease, medicine, TBARS, Humans, Sulfhydryl Compounds, Aged, Ultrasonography, chemistry.chemical_classification, Glutathione Peroxidase, General Immunology and Microbiology, medicine.diagnostic_test, Superoxide Dismutase, business.industry, Glutathione peroxidase, lcsh:R, Fatty liver, General Medicine, Middle Aged, medicine.disease, Oxidative Stress, chemistry, Cardiovascular Diseases, Female, 030211 gastroenterology & hepatology, Hemodialysis, Liver function tests, business, Oxidative stress, Research Article |
| الوصف: | Introduction. Nonalcoholic fatty liver disease (NAFLD) is becoming more common around the world and it may progress to cirrhosis and liver failure, increasing mortality risk. In hemodialysis (HD) patients, NAFLD may be a novel risk factor for their high cardiovascular mortality. Heightened oxidative stress is highly prevalent in HD patients. However, the relationship between oxidative stress and NAFLD in HD patients is not well defined.Methods. We studied seventy-one stable nondiabetic HD patients. Nineteen patients had the diagnosis of NAFLD by ultrasonography. Blood levels of oxidative stress markers were measured in each patient, including thiobarbituric acid reactive substances (TBARS), free thiols, superoxide dismutase (SOD) activities, and glutathione peroxidase (GPx) activity. The copy numbers of mitochondrial DNA (mtDNA) in peripheral leukocytes were also determined. Demographic, biochemistry, and hemogram data were recorded. The two groups of patients were compared in order to determine the factors associated with NAFLD in HD patients.Findings. Compared to those without NAFLD, nondiabetic HD patients with NAFLD had significantly higher mtDNA copy number and GPx levels. The two groups did not differ significantly in dialysis adequacy, hemoglobin, serum calcium, phosphorus, albumin, liver function tests, or lipid profiles. Regression analysis confirmed mtDNA copy numbers and GPx levels as two independent factors associated with NAFLD. Compared to those with polysulfone, patients dialyzed with cellulose membrane have significantly higher levels of TBARS. However, patients with or without NAFLD did not differ in their use of either dialysis membrane.Discussion. Oxidative stress (represented by antioxidant defense, GPx) and mitochondrial DNA copy numbers are independently associated with fatty liver disease in nondiabetic HD patients. The diagnostic and therapeutic implications of this key observation warrant further exploration. |
| وصف الملف: | text/xhtml |
| اللغة: | English |
| تدمد: | 2314-6141 2314-6133 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2a9ee8906fdd587aeb0fbb7314d35bc http://europepmc.org/articles/PMC6236669 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b2a9ee8906fdd587aeb0fbb7314d35bc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23146141 23146133 |
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