Hyperphagia and increased meal size are responsible for weight gain in rats treated sub-chronically with olanzapine
| العنوان: | Hyperphagia and increased meal size are responsible for weight gain in rats treated sub-chronically with olanzapine |
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| المؤلفون: | Peter G. Clifton, Mikhail Kalinichev, Sergei Korneev, Nima Davoodi |
| المصدر: | Psychopharmacology. 203:693-702 |
| بيانات النشر: | Springer Science and Business Media LLC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Olanzapine, medicine.medical_specialty, Pro-Opiomelanocortin, Melanin-concentrating hormone, medicine.drug_class, media_common.quotation_subject, Atypical antipsychotic, Hyperphagia, Weight Gain, Rats, Sprague-Dawley, Benzodiazepines, Eating, chemistry.chemical_compound, Internal medicine, Animals, Medicine, Neuropeptide Y, RNA, Messenger, media_common, Pharmacology, Orexins, Meal, business.industry, Neuropeptides, digestive, oral, and skin physiology, Intracellular Signaling Peptides and Proteins, Appetite, Rats, Orexin, Endocrinology, chemistry, Hypothalamus, Female, medicine.symptom, business, Weight gain, Antipsychotic Agents, medicine.drug |
| الوصف: | Atypical antipsychotic-induced weight gain is a significant impediment in the treatment of schizophrenia. In a putative model of antipsychotic drug-induced weight gain, we investigated the effects of sub-chronic olanzapine on body weight, meal patterns, the expression of genes encoding for hypothalamic feeding-related neuropeptides and the contribution of hyperphagia to olanzapine-induced weight gain in rats. In experiment 1, female rats received either olanzapine (1 mg/kg, p.o.) or vehicle, twice daily for 7 days, while meal patterns were recorded. At the end of the treatment regimen, we measured the levels of hypothalamic messenger RNAs (mRNAs) encoding neuropeptide-Y (NPY), hypocretin/orexin (HCRT), melanin concentrating hormone and pro-opiomelanocortin. NPY and HCRT mRNA levels were also assessed in a separate cohort of female rats treated acutely with olanzapine (1 mg/kg, p.o.). In experiment 2, we investigated the effect of a pair-feeding paradigm on sub-chronic (1 mg/kg, p.o.) olanzapine-induced weight gain. In experiment 1, sub-chronic olanzapine increased body weight, food intake and meal size. Hypothalamic neuropeptide mRNA levels were unchanged after both acute and sub-chronic olanzapine treatment. In experiment 2, the restriction of food intake to the level of vehicle-treated controls abolished the sub-chronic olanzapine-induced increase in body weight. Hyperphagia mediated by drug-induced impairments in satiety (as evidenced by increased meal size) is a key requirement for olanzapine-induced weight gain in this paradigm. However, olanzapine-induced hyperphagia and weight gain may not be mediated via alterations in the expression of the feeding-related hypothalamic neuropeptides examined in this study. |
| تدمد: | 1432-2072 0033-3158 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2c14250f9a6ccfdeef52e0f5a05d20c https://doi.org/10.1007/s00213-008-1415-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....b2c14250f9a6ccfdeef52e0f5a05d20c |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14322072 00333158 |
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