التفاصيل البيبلوغرافية
العنوان:
Data from Minimal Residual Disease after Conventional Treatment Significantly Impacts on Progression-Free Survival of Patients with Follicular Lymphoma: The FIL FOLL05 Trial
المؤلفون:
Massimo Federico , Mario Petrini , Pellegrino Musto , Gianluca Gaidano , Giovanni Bertoldero , Daniele Vallisa , Carola Boccomini , Umberto Vitolo , Alessandro Pulsoni , Luigi Rigacci , Giuseppe Alberto Palumbo , Alessandra Tucci , Luca Arcaini , Marzia Cavalli , Irene Della Starza , Ilaria Del Giudice , Barbara Mantoan , Luigia Monitillo , Claudia Mannu , Anna Gazzola , Pier Paolo Piccaluga , Marco Ladetto , Luigi Marcheselli , Alessandra Dondi , Francesca Guerrini , Susanna Grassi , Elena Ciabatti , Stefano Luminari , Sara Galimberti
بيانات النشر:
American Association for Cancer Research (AACR), 2023.
سنة النشر:
2023
الوصف:
Purpose: The role of the minimal residual disease (MRD) in follicular lymphoma is still debated. In this study, we assessed whether the BCL2/IGH rearrangement could have a prognostic role in patients receiving R-CHOP, R-FM, or R-CVP.Experimental Design: DNAs from 415 patients among the 504 cases enrolled in the FOLL05 trial (NCT00774826) were centralized and assessed for the BCL2/IGH at diagnosis, at the end of treatment, and after 12 and 24 months.Results: At diagnosis, the molecular marker was detected in 53% of cases. Patients without molecular marker or with a low molecular tumor burden (−4 copies) showed higher complete remission (CR) rate and longer progression-free survival (PFS; 3-year PFS 80% vs. 59%; P = 0.015). PFS was significantly conditioned by the PCR status at 12 and 24 months, with 3-year PFS of 66% for MRD− cases versus 41% for those MRD+ at 12 months (P = 0.015), and 84% versus 50% at 24 months (P = 0.014). The MRD negativity at 12 and 24 months resulted in an improved PFS both in CR and in partial remission (PR) patients (3-year PFS = 72% for cases CR/PCR− vs. 32% for those CR/PCR+ vs. 62% for those PR/PCR− and 25% for patients in PR/PCR+; P = 0.001). The prognostic value of MRD at 12 and 24 months of follow-up was confirmed also in multivariate analysis.Conclusions: In this study, standardized molecular techniques have been adopted and applied on bone marrow samples from a large cohort. Data reported show that the MRD detection is a powerful independent predictor of PFS in patients with follicular lymphoma receiving conventional chemoimmunotherapy. Clin Cancer Res; 20(24); 6398–405. ©2014 AACR.
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ce70ec1391d4091e58b90eef2f5b9e https://doi.org/10.1158/1078-0432.c.6524198
حقوق:
OPEN
رقم الأكسشن:
edsair.doi.dedup.....b2ce70ec1391d4091e58b90eef2f5b9e
قاعدة البيانات:
OpenAIRE
