Impairment in the goal-directed corticostriatal learning system as a biomarker for obsessive–compulsive disorder
| العنوان: | Impairment in the goal-directed corticostriatal learning system as a biomarker for obsessive–compulsive disorder |
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| المؤلفون: | Qiong Yang, Yuping Ning, Ziwen Peng, Qi Chen, Jingjing Liang, Chenjie Dong, Carol A Seger, Hongying Han |
| المصدر: | Psychological Medicine. 50:1490-1500 |
| بيانات النشر: | Cambridge University Press (CUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Obsessive-Compulsive Disorder, Adolescent, Prefrontal Cortex, Striatum, Nucleus accumbens, behavioral disciplines and activities, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Obsessive compulsive, Neural Pathways, Humans, Learning, Medicine, Prefrontal cortex, Applied Psychology, Cerebral Cortex, Brain Mapping, Granger causality analysis, medicine.diagnostic_test, business.industry, Putamen, Middle Aged, Magnetic Resonance Imaging, Corpus Striatum, 030227 psychiatry, Psychiatry and Mental health, Case-Control Studies, Biomarker (medicine), Female, business, Functional magnetic resonance imaging, Goals, Neuroscience, Biomarkers, 030217 neurology & neurosurgery |
| الوصف: | BackgroundCompulsive behaviors in obsessive-compulsive disorder (OCD) have been related to impairment within the associative cortical-striatal system connecting the caudate and prefrontal cortex that underlies consciously-controlled goal-directed learning and behavior. However, little is known whether this impairment may serve as a biomarker for vulnerability to OCD.MethodsUsing resting-state functional magnetic resonance imaging (fMRI), we employed Granger causality analysis (GCA) to measure effective connectivity (EC) in previously validated striatal sub-regions, including the caudate, putamen, and the nucleus accumbens, in 35 OCD patients, 35 unaffected first-degree relatives and 35 matched healthy controls.ResultsBoth OCD patients and their first-degree relatives showed greater EC than controls between the left caudate and the orbital frontal cortex (OFC). Both OCD patients and their first-degree relatives showed lower EC than controls between the left caudate and lateral prefrontal cortex. These results are consistent with findings from task-related fMRI studies which found impairment in the goal-directed system in OCD patients.ConclusionsThe same changes in EC were present in both OCD patients and their unaffected first-degree relatives suggest that impairment in the goal-directed learning system may be a biomarker for OCD. |
| تدمد: | 1469-8978 0033-2917 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2d848ccd8467787a14c05768f33136a https://doi.org/10.1017/s0033291719001429 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....b2d848ccd8467787a14c05768f33136a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14698978 00332917 |
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