Natural Killer Cell-Derived IL-10 Prevents Liver Damage During Sustained Murine Cytomegalovirus Infection
| العنوان: | Natural Killer Cell-Derived IL-10 Prevents Liver Damage During Sustained Murine Cytomegalovirus Infection |
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| المؤلفون: | Alaa Kassim Ali, Amandeep Kaur Komal, Saeedah Musaed Almutairi, Seung-Hwan Lee |
| المصدر: | Frontiers in Immunology, Vol 10 (2019) Frontiers in Immunology |
| بيانات النشر: | Frontiers Media S.A., 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, lcsh:Immunologic diseases. Allergy, Muromegalovirus, immunoregulation, T-Lymphocytes, medicine.medical_treatment, T cell, Immunology, Inflammation, Biology, Lymphocyte Activation, Natural killer cell, Mice, 03 medical and health sciences, 0302 clinical medicine, Immune system, Immunopathology, medicine, Animals, Immunology and Allergy, Original Research, Innate immune system, natural killer cells, Herpesviridae Infections, Interleukin-10, 3. Good health, Killer Cells, Natural, Disease Models, Animal, Interleukin 10, 030104 developmental biology, medicine.anatomical_structure, Cytokine, Liver, inflammation, liver damage, IL-10, medicine.symptom, lcsh:RC581-607, MCMV, 030215 immunology |
| الوصف: | Natural Killer (NK) cells are lymphocytes of the innate immune response that play a vital role in controlling infections and cancer. Their pro-inflammatory role has been well-established; however, less is known about the regulatory functions of NK cells, in particular, their production of the anti-inflammatory cytokine IL-10. In this study, we investigated the immunoregulatory function of NK cells during MCMV infection and demonstrated that NK cells are major producers of IL-10 during the early stage of infection. To investigate the effect of NK cell-derived IL-10, we have generated NK cell-specific IL-10-deficient mice (NKp46-Cre-Il10 fl/fl ) displaying no signs of age-related spontaneous inflammation, with NK cells that show no detectable IL-10 production upon in vitro stimulation. In NKp46-Cre-Il10 fl/fl mice, the levels of IL-10 and IFNγ, viral burdens and T cell activation were similar between NKp46-Cre-Il10 fl/fl mice and their control littermates, suggesting that NK cell-derived IL-10 is dispensable during acute MCMV infection in immunocompetent hosts. In perforin-deficient mice that show a more sustained infection, NK cells produce more sustained levels of IL-10. By crossing NKp46-Cre-Il10 fl/fl mice with perforin-deficient mice, we demonstrated that NK cell-derived IL-10 regulates T cell activation, prevents liver damage, and allows for better disease outcome. Taken together, NK cell-derived IL-10 can be critical in regulating the immune response during early phases of infection and therefore protecting the host from excessive immunopathology. |
| اللغة: | English |
| تدمد: | 1664-3224 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b33375805c3785c44246b38410ee1f93 https://www.frontiersin.org/article/10.3389/fimmu.2019.02688/full |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....b33375805c3785c44246b38410ee1f93 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16643224 |
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